Effects of butylphthalide combined with urinary kallidinogenase on cognitive function and serological indexes in patients with acute phase of cerebral infarction
Objective To investigate the effects of butylphthalide combined with urinary kallidinogenase on cognitive function and serological indexes in patients with acute phase of cerebral infarction.Methods 48 patients with acute phase of cerebral infarction were divided into the control group and the observation group according to random number table method,with 24 cases in each group.All patients received routine treatment after admission,the control group was additionally given urinary kallidinogenase for injection,and the observation group was additionally given butylphthalide soft capsules on the basis of the control group.The clinical efficacy,cognitive function,vascular endothelial function and oxidative stress level were compared between the two groups.Results After treatment,the total effective rate of 91.67%in the observation group was higher than 66.67%in the control group(P<0.05).After treatment,the scores of the Montreal Cognitive Assessment Scale(MoCA)in both groups were significantly higher than those before treatment;the scores of orientation,choice,abstraction,visuospatial function,naming,attention and language in the observation group were(4.94±0.48),(5.04±0.47),(1.90±0.48),(4.67±1.05),(2.76±0.76),(5.13±0.95)and(2.66±0.86)points,which were higher than(3.51±0.32),(3.89±0.28),(0.95±0.28),(3.42±0.48),(1.90±0.47),(4.27±0.66)and(1.93±0.47)points in the control group(P<0.05).After treatment,the serum levels of endothelin-1(ET-1),nitric oxide(NO),nitric oxide synthase(NOS)and vascular endothelial growth factor(VEGF)in both groups were lower than those before treatment;the observation group had ET-1 of(77.26±10.96)ng/L,NO of(33.81±5.63)μmol/L,NOS of(13.59±4.53)μmol/L,VEGF of(212.96±24.45)ng/L,which were lower than(107.71±11.58)ng/L,(49.74±8.99)μmol/L,(26.32±6.33)μmol/L,(278.87±28.94)ng/L in the control group;the difference was statistically significant(P<0.05).After treatment,the serum levels of matrix metalloproteinase-9(MMP-9)and malondialdehyde(MDA)in both groups were lower than those before treatment,and the serum levels of total antioxidant capacity(T-AOC)and superoxide dismutase(SOD)were higher than those before treatment;MMP-9 of(122.72±26.04)U/ml and MDA of(3.08±0.44)μmol/L in the observation group were lower than(161.63±28.66)U/ml and(4.14±0.97)μmol/L in the control group;T-AOC of(12.10±0.61)U/ml and SOD of(96.17±13.35)U/ml in the observation group were higher than(10.52±0.67)and(80.53±28.97)U/ml in the control group;the difference was statistically significant(P<0.05).Conclusion In patients with acute phase of cerebral infarction,butylphthalide combined with urinary kallidinogenase can improve clinical efficacy,cognitive function,reduce vascular endothelial injury and improve oxidative stress response.
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