Clinical effect of probiotics combined with bismuth-containing quadruple treatment for patients with Helicobacter pylori positive chronic gastritis
Objective To explore the clinical effect of probiotics combined with bismuth-containing quadruple treatment for patients with Helicobacter pylori(Hp)positive chronic gastritis.Methods 80 patients with Hp positive chronic gastritis were divided into an observation group and a control group according to different treatment methods,with 40 cases in each group.The observation group received probiotics and bismuth-containing quadruple treatment,and the control group received bismuth-containing quadruple treatment alone.The clinical efficacy,Hp eradication rate,incidence of adverse reactions,symptom scores and the changes of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and gastrin(GS)before and after treatment were compared between the two groups.Results After 2 weeks of treatment,the scores of upper abdominal pain,belching and acid reflux,nausea and vomiting were decreased in both groups;the scores of upper abdominal pain,belching and acid reflux,nausea and vomiting in the observation group were(0.72±0.64),(0.36±0.29)and(0.52±0.40)points,which were lower than(1.09±0.70),(0.98±0.79)and(1.03±0.94)points in the control group(P<0.05).The total clinical effective rate of the observation group(97.50%)was higher than that of the control group(82.50%)(P<0.05).The Hp eradication rate in the observation group(100.00%)was higher than that in the control group(87.50%)(P<0.05).After 2 weeks of treatment,the PGⅠ,PGⅡ and GS were decreased in both groups;the observation group had PGⅠ of(74.11±13.24)μg/L,PGⅡ of(4.92±1.79)μg/L and GS of(63.26±6.02)pg/ml,which were lower than(101.56±16.33)μg/L,(9.36±2.31)μg/L and(79.33±6.47)pg/m in the control group(P<0.05).The total incidence of adverse reactions in the observation group(10.00%)was lower than that in the control group(30.00%)(P<0.05).Conclusion Probiotics combined with bismuth-containing quadruple treatment has significant effect on for patients with Hp positive chronic gastritis,and can improve the clinical symptoms of patients.The eradication rate of HP is high and the risk of adverse reactions is low.
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