Study on correlation of cognitive function and serum neurofilament light chain and homocysteine levels in patients with cerebral small vessel disease
Objective To explore the correlation of cognitive function and serum neurofilament light chain(NFL)and homocysteine(Hcy)levels in patients with cerebral small vessel disease(CSVD).Methods 100 patients with cerebral small vascular disease were divided into cognitive normal group and cognitive impairment group according to different scores of Montreal Cognitive Assessment Scale(MoCA),with 50 cases in each group.Basic data were collected and serum levels of serum neurofilament light chain and homocysteine were detected.Multivariate Logistic regression was used to analyze the influencing factors of cognitive dysfunction in patients with cerebral small vessel disease,and Pearson correlation was used to analyze the correlation of cognitive function and serum neurofilament light chain and homocysteine levels in patients with cerebral small vessel disease.Results The levels of serum neurofilament light chain in the cognitive impairment group were(200.89±11.25)pg/ml and(39.58±6.34)μmol/L,respectively,which were higher than(168.57±11.34)pg/ml and(30.54±7.12)μmol/L in the cognitive normal group,respectively.The differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum neurofilament light chain and homocysteine levels were significantly negatively correlated with MoCA scores in patients with cerebral small vessel disease(r=-0.658,-0.756;P<0.05).There was no significant difference in age,sex,years of education,history of drinking,history of smoking and history of coronary heart disease between the two groups(P>0.05).The history of hypertension and diabetes mellitus in the cognitive impairment group was higher than that in the cognitive normal group,and the MoCA score was lower than that in the cognitive normal group.The difference was statistically significant(P<0.05).Logistic regression analysis showed that the history of hypertension and the levels of serum neurofilament light chain and homocysteine were the influencing factors of cognitive impairment in patients with cerebral small vessel disease(P<0.05).Conclusion Serum neurofilament light chain and homocysteine levels are correlated with cognitive function in patients with cerebral small vascular disease.The levels of serum neurofilament light chain and homocysteine are the risk factors of cognitive impairment in cerebral small vascular disease,and the detection of neurofilament light chain and homocysteine in patients with cerebral small vascular disease or suspected cerebral small vascular disease is of great significance,which can provide reference for the early diagnosis and prognosis of cerebral small vascular disease.
Cerebral small vessel diseaseCognitive functionSerum neurofilament light chainHomocysteineCorrelation
万方数据
维普
