Clinical study of transcranial Doppler ultrasound combined with low-dose alteplase intravenous thrombolysis in the treatment of acute cerebral infarction
Objective To analyze the effect of transcranial Doppler ultrasound combined with low-dose alteplase intravenous thrombolysis in the treatment of acute cerebral infarction.Methods A total of 50 patients with acute cerebral infarction were selected as the research subjects.They were divided into a study group and a control group according to the random number table method,each with 25 cases.The study group was treated with transcranial Doppler ultrasound + 0.6 mg/kg low-dose(the highest total dose≤50 mg)alteplase intravenous thrombolysis,and the control group was treated with 0.9 mg/kg alteplase(the highest dose≤90 mg)intravenous thrombolysis.The middle cerebral artery hemodynamics,National Institutes of Health Stroke Scale(NIHSS)score,vascular revascularization rate and adverse reactions were compared between the two groups.Results In the study group,the end-diastolic velocity(Vd),mean velocity(Vm)and peak systolic velocity(Vp)were(23.75±10.25),(40.53±10.15)and(81.26±15.14)cm/s,which were faster than(18.22±7.23),(32.47±10.16)and(70.30±15.12)cm/s in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in NIHSS scores between the two groups before and 2 h after thrombolysis(P>0.05).24 h and 28 d after thrombolysis,the NIHSS scores of the study group were(9.45±1.19)and(7.25±1.17)points,which were lower than(12.33±1.13)and(8.12±1.19)points of the control group,and the differences were statistically significant(P<0.05).The vascular revascularization rate in the control group was 76.00%,which was lower than 96.00%in the study group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 24.00%,which was higher than 4.00%in the study group,and the difference was statistically significant(P<0.05).Conclusion Transcranial Doppler ultrasound combined with low-dose alteplase intravenous thrombolysis is of high value,which can help patients improve neurological function and hemodynamics,and has positive significance for speeding up the process of disease recovery,which can be promoted.
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