Value analysis of trimetazidine combined with clopidogrel in the treatment of angina pectoris of coronary heart disease
Objective To analyze the value of trimetazidine combined with clopidogrel in the treatment of angina pectoris of coronary heart disease.Methods 150 patients with angina pectoris of coronary heart disease were randomly divided into a control group and an observation group,with 75 cases in each group.The control group was treated with trimetazidine,and the observation group was treated with trimetazidine and clopidogrel.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions,levels of inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),endothelin-1(ET-1)],cardiac function indicators[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)]before and after treatment,clinical indicators(ST segment depression in electrocardiogram,frequency of angina attacks,duration of angina pectoris).Results The total effective rate of 97.33%in the observation group was higher than 86.67%in the control group(P<0.05).After treatment,the levels of TNF-α,hs-CRP and ET-1 in both groups were significantly decreased compared with those before treatment;the observation group had TNF-α of(21.59±1.94)ng/L,hs-CRP of(2.53±0.22)mg/L,ET-1 of(71.74±5.53)ng/L,which were lower than(27.29±2.52)ng/L,(4.09±0.37)mg/L,(84.26±6.72)ng/L in the control group(P<0.05).After treatment,LVEDD,LVESD and LVEF in both groups were significantly improved compared with those before treatment;the observation group had LVEDD of(46.29±3.37)mm,LVESD of(34.06±3.21)mm and LVEF of(48.24±4.64)%,which were better than(50.33±3.76)mm,(37.78±3.53)mm and(40.94±3.83)%in the control group(P<0.05).After treatment,the degree of ST segment depression in electrocardiogram in both groups was lower than that before treatment,the frequency of angina attacks was lower than that before treatment,and the duration of angina pectoris was shorter than that before treatment;in the observation group,the ST segment depression in electrocardiogram of(0.51±0.03)mm was lower than(0.86±0.07)mm in the control group,the frequency of angina attacks of(2.04±0.18)attacks per week was lower than(3.94±0.37)attacks per week in the control group,and the duration of angina pectoris(3.01±0.26)min/attack was shorter than(5.29±0.49)min/attack in the control group(P<0.05).The incidence of adverse reactions in the observation group was 5.33%,which was slightly higher than 4.00%in control group,but there was no difference(P>0.05).Conclusion Trimetazidine combined with clopidogrel can better improve the cardiac function of patients with angina pectoris of coronary heart disease,improve the level of inflammatory factors and symptoms of patients,with high therapeutic efficiency and fewer adverse effects,which is of high clinical value.
万方数据
维普
