Study on the effect of compound metronidazole suppository in the treatment of bacterial vaginitis
Objective To explore the clinical efficacy and safety of compound metronidazole suppository in the treatment of bacterial vaginitis.Methods A total of 360 patients with bacterial vaginitis who met the inclusion criteria were divided into control group A,control group B and experimental group by random number table method,with 120 cases in each group.The control group A was treated with metronidazole suppository,the control group B was treated with metronidazole vaginal effervescent tablet,and the experimental group was treated with compound metronidazole suppository.The rate of negative conversion,vaginal cleanliness,daytime pruritus score before and after treatment,recurrence,adverse reactions,and drug compliance were compared among the three groups.Results The rate of negative conversion of the experimental group was 85.00％,that of the control group A was 67.50％,and that of the control group B was 70.83％.The rate of negative conversion in the experimental group was higher than that in control group A and control group B,and the difference was statistically significant(P<0.05).After treatment,the proportion of Ⅰ degree of vaginal cleanliness in the experimental group was 76.67％,which was higher than 47.50％in the control group A and 51.67％in the control group B;the proportion of Ⅱ and Ⅲ degree of vaginal cleanliness were 18.33％and 5.00％,which were significantly lower than 30.00％and 22.50％in the control group A and 30.83％and 17.50％in the control group B;the difference was statistically significant(P<0.05).After treatment,the daytime itch score of all groups was lower than that before treatment;the daytime pruritus score was(0.87±0.21)points in the experimental group,which was lower than(2.26±0.27)points in the control group A and(2.14±0.37)points in the control group B;the difference was statistically significant(P<0.05).The recurrence rate of the experimental group was 3.33％,which was significantly lower than 14.17％of the control group A and 10.83％of the control group B,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 1.67％,which was significantly lower than 13.33％in the control group A and 10.00％in the control group B,and the difference was statistically significant(P<0.05).The drug compliance rate of the experimental group was 97.50％,which was higher than 82.50％of control group A and 85.83％of the control group B,and the difference was statistically significant(P<0.05).Conclusion Compound metronidazole suppository in the treatment of bacterial vaginitis can significantly improve the rate of negative conversion,improve daytime pruritus symptoms and vaginal cleanliness,reduce the recurrence rate and the incidence of adverse reactions,and the patient compliance is better than compound metronidazole vaginal suppository and metronidazole vaginal effervescent tablet.
万方数据
维普
