Clinical observation of butorphanol combined with dexmedetomidine for lower limb nerve block anesthesia
Objective To investigate the clinical effect of butorphanol combined with dexmedetomidine in lower limb nerve block anesthesia.Methods A total of 80 patients undergoing lower limb surgery were divided into a control group and a study group using a numerical table method,each with 40 cases.Lower limb nerve block anesthesia was performed in both groups during surgery,with butorphanol in the control group and butorphanol combined with dexmedetomidine in the study group.Both groups were compared in terms of anesthesia block time,heart rate and mean arterial pressure at different time periods(before surgery,during nerve block,after surgery),stress indicators[norepinephrine(NE),cortisol(Cor),and adrenaline(E)]before and after surgery,and incidence of adverse reactions.Results Compared with the control group,the onset time was shorter,and the duration of anesthesia block and duration of analgesia were longer in the study group(P<0.05).During nerve block,the heart rate of control group was(86.54±4.15)beats/min,and the mean arterial pressure was(93.54±4.34)mm Hg(1 mm Hg= 0.133 kPa);the heart rate of the study group was(63.54±3.24)beats/min,and the mean arterial pressure was(90.61±4.51)mm Hg.Compared with the control group,the heart rate and mean arterial pressure in the study group were lower(t=27.629,2.961;P<0.05).After surgery,the heart rate of the control group was(73.54±3.34)beats/min,and the mean arterial pressure was(97.55±5.12)mm Hg;the heart rate of the study group was(64.05±3.18)beats/min,and the mean arterial pressure was(92.34±4.39)mm Hg.Compared with the control group,the heart rate and mean arterial pressure in the study group were lower(t=13.015,4.886;P<0.05).After surgery,the NE,Cor and E of the control group were(451.25±25.12)ng/L,(844.15±31.15)nmol/L and(741.25±30.15)pmol/L,and those of the study group were(344.85±24.05)ng/L,(721.35±28.46)nmol/L and(552.41±23.28)pmol/L.The stress indicators in both groups were higher than those before surgery,but NE,Cor and E in the study group were lower than those in the control group(t=19.350,18.407,31.354;P<0.05).The incidence of adverse reactions in the study group was 5.00%,which was lower than 22.50%in the control group(P<0.05).Conclusion The use of butorphanol combined with dexmedetomidine in lower limb nerve block anesthesia has significant effects,which can shorten the duration of anesthesia block,stabilize intraoperative stress indicators,reduce the incidence of postoperative complications,and has high safety.
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