Analysis of clinical effect and safety of modified Zhike Powder in the treatment of senile pneumonia
Objective To explore the clinical effect and safety of Zhike Powder in the treatment of senile pneumonia.Methods 98 senile patients with pneumonia were randomly divided into a control group and an observation,with 49 patients in each group.The control group was treated with routine symptomatic treatment,and the observation group was treated with modified Zhike Powder.The clinical efficacy,treatment index(fever reduction time,cough relief time,expectorant time,hospital stay),serum inflammatory factor(tumor necrosis factor-α,interleukin-6 and hypersensitive C-reactive protein)levels and incidence of adverse events were compared between the two groups.Results In the control group,13 cases were significantly effective,26 cases were effective,10 cases were ineffective,and the total effective rate was 79.59%(39/49).In the observation group,17 cases were significantly effective,30 cases were effective and 2 cases were ineffective,and the total effective rate was 95.92%(47/49).The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).In the observation group,the fever reduction time was(1.70±0.49)d,the cough relief time was(2.57±0.68)d,the expectorant time was(4.12±1.02)d,and the hospital stay was(5.78±1.27)d,which were shorter than(4.18±0.92),(3.74±0.81),(5.75±1.44),and(11.95±2.62)d in the control group(P<0.05).After treatment,the tumor necrosis factor-α of the observation group was(1.12±0.32)ng/L,the interleukin-6 was(5.41±1.18)pg/L,and the hypersensitive C-reactive protein was(8.87±2.25)mg/L,which were lower than(1.60±0.38)ng/L,(9.48±1.48)pg/L,and(12.34±2.47)mg/L of the control group(P<0.05).The incidence of adverse events in the observation group was 6.12%(3/49),which was lower than 20.41%(10/49)in the control group(P<0.05).Conclusion Modified Zhike Powder shows significant effect on senile patients with pneumonia,the time of symptom improvement is short,the inflammatory reaction is significantly reduced,and the safety after treatment is high,which is worthy of clinical promotion.
万方数据
维普
