Effect analysis of ACEI and ARB on prognosis of patients with chronic kidney disease
Objective To explore the effect of angiotensin converting enzyme inhibitor(ACEI)and angiotensin receptor blocker(ARB)on prognosis of patients with chronic kidney disease(CKD).Methods 88 patients with chronic kidney disease were randomly divided into a control group and an observation group,with 44 cases in each group.The control group was treated with ACEI,and the observation group was treated with ARB.The therapeutic effect,renal function related indicators,cardiac function indicators,quality of life score and adverse reactions were compared between the two groups.Results The total effective rate of treatment was high in both groups(P>0.05).After treatment,the observation group had urea nitrogen of(9.25±1.05)mmol/L and serum creatinine of(142.56±32.08)μmol/L,which were lower than(12.56±5.25)mmol/L and(252.26±55.16)μmol/L in the control group;the serum creatinine clearance rate of(96.41±2.08)ml/min in the observation group was higher than(88.56±8.25)ml/min in the control group(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)in the observation group were(46.25±1.06)and(50.26±0.36)mm,which were less than(49.26±5.26)and(57.15±2.56)mm in the control group;the left ventricular ejection fraction(LVEF)of(44.89±1.08)%in the observation group was higher than(41.26±5.62)%in the control group(P<0.05).After treatment,the scores of vitality,role-physical,role-emotional and social function in the observation group were(68.44±1.54),(64.99±2.10),(68.48±2.15)and(62.48±1.08)points,which were higher than(59.48±6.50),(58.48±8.10),(59.48±8.41)and(59.71±0.36)points in the control group(P<0.05).The incidence of adverse reactions was low in both groups(P>0.05).Conclusion Both ACEI and ARB have certain efficacy in the treatment of chronic kidney disease,but ARB can significantly improve the renal function and cardiac function indicators of patients,and is more helpful to improve their quality of life.
Angiotensin converting enzyme inhibitorAngiotensin Ⅱ receptor antagonistChronic kidney diseaseRenal function
万方数据
维普
