Analysis of correlation between colorectal polyps and blood lipid levels
Objective To explore the correlation between colorectal polyps and blood lipid levels.Methods 78 patients with colorectal polyps were selected as the observation group,and concurrent 78 patients with normal colonoscopy were selected as the control group.The blood lipid indicators[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),apolipoprotein(Apo)A1,Apo B,Apo E,lipoprotein a(Lpa)]of the two groups were compared,as well as the lipid indicators of different pathological subtypes within the observation group.The correlation between blood lipid indicators and colorectal polyp was analyzed.Results The observation group had TG of(1.58±0.57)mmol/L,TC of(5.25±1.10)mmol/L,LDL-C of(3.41±0.82)mmol/L,Apo B of(0.98±0.26)g/L,Lpa of(140.98±27.65)mg/L,which were higher than(1.19±0.36)mmol/L,(4.38±0.86)mmol/L,(2.57±0.73)mmol/L,(0.80±0.21)g/L,(82.79±20.04)mg/L in the control group;the observation group had lower HDL-C of(1.14±0.31)mmol/L than(1.48±0.42)mmol/L in the control group(P<0.05).There were no significant differences in Apo A1 and Apo E levels between the two groups(P>0.05).There were significant differences in the levels of TG,TC,LDL-C,HDL-C,Apo B and Lpa among different pathological subtypes in the observation group(P<0.05).The levels of TG,TC,LDL-C,Apo B and Lpa in adenomatous polyps were higher than those in inflammatory polyps and hyperplastic polyps,and the levels of HDL-C were lower than those in inflammatory polyps and hyperplastic polyps(P<0.05).There were no significant differences in Apo A1 and Apo E levels among different pathological subtypes in the observation group(P>0.05).Spearman correlation analysis showed that the levels of TG,LDL-C,Apo B and Lpa were positively correlated with the incidence of colorectal polyps(r=0.161,0.170,0.186,0.178;P<0.05).There was no significant correlation between the levels of TC,HDL-C,Apo A1 and Apo E and the incidence of colorectal polyps(r=0.062,0.071,0.060,0.064;P>0.05).Conclusion The incidence of colorectal polyps is positively correlated with the levels of TG,LDL-C,Apo B and Lpa in blood lipids,and the blood lipid levels of adenomatous polyps are the most disregulated.Clinically,dyslipidemia can be regarded as a risk factor for colorectal polyps.
万方数据
维普
