Investigation of bacterial flora in children with bacterial meningitis syndrome and analysis of susceptibility and drug resistance
Objective To investigate the bacterial flora and drug resistance of children with bacterial meningitis syndrome.Methods A total of 199 children with bacterial meningitis syndrome were selected as the study subjects.Cerebrospinal fluid specimens of all children were collected to complete bacterial culture and drug sensitivity test.The distribution of pathogenic bacteria and drug resistance characteristics of main pathogenic bacteria were analyzed.Results A total of 61 strains of pathogenic bacteria were detected in the cerebrospinal fluid of 199 children,which were Streptococcus pneumoniae,Streptococcus,Escherichia coli,Staphylococcus aureus,Coagulase-negative staphylococci,Enterococcus faecalis,Candida albicans,Neisseria meningitidis and others in descending order of their percentage,with the percentages being 31.15%,21.31%,19.67%,16.39%,3.28%,respectively,3.28%,1.64%,1.64%,and 1.64%.Escherichia coli had no resistance to imipenem as well as meropenem,and varying degrees of resistance to other antimicrobials;Neisseria meningitidis had no resistance to imipenem,meropenem,ceftriaxone,and cefotaxime,with varying degrees of resistance to other antimicrobials;Streptococcus pneumoniae had no resistance to vancomycin,and varying degrees of resistance to other antimicrobials;Streptococcus had no resistance to cefoperazone,7.69%resistance to ciprofloxacin,and significant resistance to all other antimicrobials;Staphylococcus aureus had no resistance to vancomycin as well as linezolid,and varying degrees of resistance to all other antimicrobials;Coagulase-negative staphylococci had no resistance to vancomycin and linezolid,and varying degrees of resistance to other antimicrobials.Conclusion Streptococcus pneumoniae,Streptococcus,Escherichia coli,Staphylococcus aureus,Coagulase-negative staphylococci and Neisseria meningitidis are the main pathogenic bacteria in children with bacterial meningitis syndrome,and different pathogenic bacteria have different drug resistance to different antimicrobials.Antimicrobials should be rationally selected according to the resuts of drug sensitivity test in clinical work.
万方数据
维普
