Clinical application of food-specific IgG antibody detection in Shan County,Shandong Province
Objective To analyze the level of food-specific immunoglobulin(IgG)antibodies in the serum of patients/children with suspected chronic food sensitivity in Shan County,Shandong Province,so as to provide a basis for the patients/children to remove disease-causing foods from their diet.Methods A total of 161 patients with suspected chronic food sensitivity were selected and divided into infant group(45 cases,≤3 years old,mean age 1.43 years old),child group(28 cases,aged 4-14 years,with an average of 8.29 years)and adolescent and adult group(88 cases,aged>14 years,with an average of 46.23 years)according to their age.Another 60 children with suspected chronic food sensitivity were selected and divided into infant group(50 cases,aged≤12 months,with an average of 5.94 months)and child group(10 cases,aged>12 months,with an average of 19.9 months)according to their age.Protein chip method was used to detect the serum levels of 20 food-specific IgG antibodies in 161 patients,and the serum levels of 17 food-specific IgG antibodies in 60 children.The positive rates of food-specific IgG antibodies in patients and children were analyzed,and the positive rates of food-specific IgG antibodies in patients or children of different age groups were compared.Results Among the 161 patients who underwent 20 food-specific IgG antibody detection,118 patients had adverse reactions to 1-18 kinds of foods,with a total positive rate of 73.29%.The top 6 positive rates among the various food-specific IgG antibodies,in descending order,were eggs(62.11%),milk(32.30%),peanuts(12.42%),wheat(8.70%),tomato(7.45%),and soybean(5.59%).Among 85 men,65(76.47%)were positive for at least 1 food-specific IgG antibody.Among 76 women,53 cases(69.74%)were positive for at least 1 food-specific IgG antibody,and there was no statistically significant difference in the total positive rate of food-specific IgG antibodies between genders(P>0.05).Among the 60 children who underwent 17 food-specific IgG antibody detection,57 children had adverse reactions to 1-11 kinds of foods,with a total positive rate of 95.00%.The top 6 positive rates among the various food-specific IgG antibodies,in descending order,were β-lactoglobulin(83.33%),milk(70.00%),skim milk powder(63.33%),cottage cheese(61.67%),goat milk(61.67%),hydrolyzed milk powder(61.67%).Among 31 boys,29(93.55%)were positive for at least 1 food-specific IgG antibody.Among 29 girls,28 cases(96.55%)were positive for at least 1 food-specific IgG antibody,and there was no statistically significant difference in the total positive rate of food-specific IgG antibodies between genders(P>0.05).Among the 161 patients who underwent 20 food-specific IgG antibody detection,the total positive rate showed a gradual decrease with age,and the total positive rate was significantly higher in the infant group and child group than in the adolescent and adult group,and the total positive rate in the infant group was significantly higher than that in the child group(P<0.05).There were significant differences in the positive rates of specific IgG antibodies in milk,egg,wheat and tomato in different age groups(P<0.05).Among them,there were significant differences in the positive rate of milk-specific IgG antibody in infant group,child group,adolescent and adult group(P<0.05).The positive rate of milk-specific IgG antibody in infant group was the highest,followed by child group,and adolescent and adult group was the lowest.The positive rates of egg and wheat specific IgG antibody in infant group and child group were significantly higher than those in adolescent group and adult group(P<0.05).The positive rate of tomato specific IgG antibody in infant group was higher than that in child group,adolescent and adult group(P<0.05).There were no significant differences in the positive rates of specific IgG antibodies in shrimp,crab,cod,potato,hazelnut,cashew nut,peach,pineapple,beef,chicken,pork,barley,corn,soybean,peanut and mushroom in different age groups(P>0.05).Among the 60 children who underwent 17 food-specific IgG antibody detection,there was no significant difference in the total positive rate of food-specific IgG antibodies between infant group and child group(P>0.05).The positive rates of specific IgG antibodies in egg,egg white,egg yolk and egg mucoid in child group were significantly higher than those in infant group(P<0.05).There were no significant differences in the positive rates of specific IgG antibody in cheddar cheese,cottage cheese,buttermilk,yogurt,goat milk,milk,buffalo milk,skim milk powder,boiled milk,hydrolyzed milk powder,α-whey protein,β-lactoglobulin and casein between two groups(P>0.05).However,the positive rate of specific IgG antibody was higher in milk,goat milk,buffalo milk,skim milk powder,hydrolyzed milk powder,cottage cheese,β-lactoglobulin,casein and other milk-related products and components in the two groups.Conclusion Detecting food-specific IgG antibodies in different populations is conducive to understanding the sensitivity of different populations to different foods in Shan County area,and the foods that cause sensitivity in the diet can be found in a timely manner,and timely adjustment of the diet is conducive to good health.
Chronic food sensitivitySpecific immunoglobulin G antibody
万方数据
维普
