Objective To analyze the clinical value of dexmedetomidine hydrochloride in anesthesia of interventional therapy for ischemic stroke.Methods A total of 80 patients with ischemic stroke who receiving interventional therapy were divided into a control group and an experimental group according to the method of computer,each with 40 cases.Both groups were given the same anesthesia induction method,the control group was given intermittent infusion of cisatracurium combined with sevoflurane inhalation,and the experimental group was given dexmedetomidine hydrochloride.The vital signs at different times,anesthetic effects and adverse reactions were compared between the two groups.Results After anesthesia and surgery,the heart rate of the experimental group were(84.25±7.16),(82.32±6.28)beats/min,and the mean arterial pressure were(92.24±3.58),(90.17±5.24)mm Hg(1 mm Hg=0.133 kPa),which were lower than(96.48±6.88),(86.81±5.77)beats/min and(103.11±4.05),(94.92±5.48)mm Hg of the control group,and there were differences between groups(P<0.05).The total excellent and good rate of anesthesia in the experimental group was 97.50%,which was higher than 82.50%in the control group,and there was difference between groups(P<0.05).The incidence of adverse reactions in the experimental group was 2.50%,which was significantly lower than 20.00%in the control group,and there was difference between groups(P<0.05).Conclusion The application of dexmedetomidine hydrochloride in the interventional anesthesia of ischemic stroke patients has significant anesthetic effect and less adverse reactions,which is worth popularizing and applying in clinical practice.