Observation of the efficacy of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)on patients with essential hypertension by ambulatory blood pressure monitor and human body component analyzer
Observation of the efficacy of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)on patients with essential hypertension by ambulatory blood pressure monitor and human body component analyzer
Objective To evaluate the efficacy of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)on patients with essential hypertension by ambulatory blood pressure monitor and human body component analyzer[antihypertensive effect and stability of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)and its effect on body composition.]Methods In 110 patients with essential hypertension,all previous antihypertensive drugs were discontinued before enrollment,and diet remained unchanged during elution.2 weeks later,all patients were treated with amlodipine besylate and benazepril hydrochloride tablets(Ⅱ),and their ambulatory blood pressure parameters[daytime,nighttime,24 h systolic blood pressure and diastolic blood pressure],smoothness index,and body composition[skeletal muscle mass,fat content,and skeletal mass index(SMI)]were monitored and compared before and after treatment.Results After treatment,the daytime,nighttime,24 h systolic blood pressure were(132.58±11.22),(120.23±12.83)and(126.10±8.11)mm Hg(1 mm Hg= 0.133 kPa),which were all lower than(148.36±10.42),(133.11±12.91)and(142.26±10.15)mm Hg before treatment;the daytime,nighttime,24 h diastolic blood pressure were(75.65±11.96),(68.31±9.10)and(71.40±8.70)mm Hg,which were lower than(85.03±10.98),(77.85±10.84)and(83.92±9.89)mm Hg before treatment;the smoothness index of(2.00±0.23)after treatment was higher than(1.21±0.26)before treatment;the difference was statistically significant(P<0.01).After treatment,the skeletal muscle mass was(35.75±6.84)kg and SMI was(8.38±0.51)kg/m2,which were higher than(25.15±6.58)kg and(7.95±0.44)kg/m2 before treatment;the fat content of(18.83±4.15)kg was lower than(23.12±4.51)kg before treatment;the difference was statistically significant(P<0.01).Conclusion Amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)for patients with essential hypertension can effectively and stably reduce ambulatory blood pressure,increase skeletal muscle mass,reduce fat content and optimize body composition,which is worthy of clinical promotion.
关键词
氨氯地平贝那普利片(Ⅱ)/原发性高血压/动态血压/人体成分
Key words
Amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)/Essential hypertension/Ambulatory blood pressure/Human body component
维普
万方数据