Clinical efficacy evaluation of nifedipine and ritodrine in the treatment of threatened premature delivery
Objective To explore and analyze the effect of nifedipine and ritodrine in the treatment of threatened premature delivery.Methods 90 pregnant women with threatened premature delivery were divided into a control group and a study group by random numerical method,with 45 cases in each group.The control group was treated with ritodrine,and the study group was treated with nifedipine.The suppression of uterine contraction after treatment,occurrence of adverse reactions during treatment,time to drug onset,prolongation of pregnancy,pregnancy outcome and neonatal condition were compared between the two groups.Results The total inhibition rate of contractions in the study group was 84.44%,which was slightly higher than 75.56%in the control group(P>0.05).The incidence of adverse reactions during treatment in the study group was only 4.44%,which was significantly lower than 17.78%in the control group(P<0.05).The study group had time to drug onset of(2.53±0.51)h and prolongation of pregnancy of(26.43±2.82)d,which were significantly better than(2.82±0.49)h and(27.94±3.78)d in the control group(P<0.05).The success rate of fetal preservation of the study group was 95.56%,which was significantly higher than 82.22%of the control group(P<0.05).There was no significant difference in neonatal weight between the two groups(P>0.05).The 1-min Apgar score of the study group was(9.68±0.25)points,which was significantly higher than(9.24±0.32)points of the control group(P<0.05).Conclusion Nifedipine combined with ritodrine for pregnant women with threatened premature delivery can effectively inhibit uterine contraction,prolong labor time,and improve pregnancy and neonatal outcomes.Compared with ritodrine,nifedipine has better effect and higher safety,and is worthy of promotion and application.
RitodrineNifedipineThreatened premature deliverySuppression of uterine contractionsAdverse reactionsTime to pregnancyNeonatal outcomes