Observation on value and adverse reactions of pranoprofen eye drops in controlling inflammation after cataract surgery
Objective To observe the application value of pranoprofen eye drops in patients with inflammation after cataract surgery and its influence on the adverse reactions.Methods 98 patients with inflammation after cataract surgery were divided into a control group and an observation group by odd-even grouping method,with 49 cases in each group.The control group was treated with fluorometholone eye drops,and the observation group was treated with pranoprofen eye drops.Both groups were compared in terms of levels of inflammatory markers[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],intraocular pressure,visual acuity and macular fovea thickness before and after treatment,ocular symptom score after treatment,clinical efficacy and incidence of adverse reactions.Results After treatment,the levels of IL-6,TNF-α and CRP in both groups were lower than those before treatment;the observation group had IL-6 of(84.36±8.26)ng/L,TNF-α of(1.06±0.08)ng/L and CRP of(8.51±0.63)mg/L,which were significantly lower than(92.38±9.05)ng/L,(1.57±0.13)ng/L and(10.36±0.85)mg/L in the control group(P<0.05).After treatment,the intraocular pressure in both groups was significantly lower than that before treatment,and the visual acuity and macular fovea thickness were significantly higher than those before treatment;the intraocular pressure of(14.08±1.22)mm Hg(1 mm Hg= 0.133 kPa)in the observation group was significantly lower than(16.77±1.45)mm Hg in the control group;the visual acuity of(0.81±0.07)and macular fovea thickness of(191.34±17.28)μm in the observation group were significantly higher than(0.54±0.04)and(179.35±16.94)μm in the control group(P<0.05).After treatment,the scores of photophobia,foreign body sensation,tears and pain in the observation group were(0.36±0.03),(0.32±0.02),(0.31±0.02)and(0.12±0.01)points,which were significantly lower than(0.52±0.04),(0.49±0.03),(0.47±0.03)and(0.31±0.02)points in the control group(P<0.05).The total clinical effective rate of 95.92%in the observation group was higher than 79.59%in the control group(P<0.05).The incidence of adverse reactions during treatment in the observation group was 6.12%,which was significantly lower than 24.49%in the control group(P<0.05).Conclusion For patients with inflammation after cataract surgery,pranoprofen eye drops can effectively reduce the level of inflammatory markers and intraocular pressure,significantly improve visual acuity,and significantly improve the score of various symptoms of patients,which has a better therapeutic effect and fewer adverse reactions.
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