摘要
目的 观察药食同源圆苞车前子壳复方治疗 2 型糖尿病的临床疗效.方法 60 例 2 型糖尿病患者,使用随机数字表法分成治疗组和对照组,每组 30 例.两组均给予西医常规治疗,治疗组在此基础上给予药食同源圆苞车前子壳复方治疗.比较两组疗效,治疗后安全性,治疗前后糖化血红蛋白(HbA1c)、中医证候积分.结果 治疗组显效 13 例、有效 7 例、无效 10 例;对照组显效 4 例、有效4 例、无效 22 例.治疗组疗效优于对照组,差异有统计学意义(Z=-3.135,P=0.002<0.05).治疗后,两组HbA1c与本组治疗前比较均下降,差异有统计学意义(P<0.05);两组治疗后HbA1c比较,差异无统计学意义(P>0.05).治疗后,两组主症积分、次症积分、舌脉积分、总积分与本组治疗前比较均下降,且治疗组主症积分、次症积分、舌脉积分、总积分分别为(0.43±0.68)、(0.90±0.61)、(0.90±0.94)、(2.23±1.14)分,低于对照组的(1.87±0.82)、(1.73±0.98)、(1.37±0.81)、(4.97±1.35)分,差异有统计学意义(P<0.05).两组治疗后心电图、血常规、生化常规、二便常规均未见特殊异常,也无明显药物毒副反应.结论 药食同源圆苞车前子壳复方治疗 2 型糖尿病的疗效确切,安全性好,能更有效改善患者中医临床症状和HbA1c指标.
Abstract
Objective To observe the clinical efficacy of compound psyllium husk of medicine-food homologous on type 2 diabetes mellitus.Methods 60 patients with type 2 diabetes mellitus were randomly divided into a treatment group and a control group according to random numerical table,with 30 cases in each group.Both groups were given conventional Western medicine treatment,and the treatment group was given compound psyllium husk of medicine-food homologous on this basis.The efficacy,safety after treatment,glycosylated hemoglobin(HbA1c)and traditional Chinese medicine syndrome score before and after treatment were compared between the two groups.Results In the treatment group,13 cases were significantly effective,7 cases were effective,10 cases were ineffective.In the control group,4 cases were significantly effective,4 cases were effective,22 cases were ineffective.The therapeutic effect of the treatment group was better than that of the control group,and the difference was statistically significant(Z=-3.135,P=0.002<0.05).After treatment,HbA1c in both groups decreased compared with that before treatment,and the difference was statistically significant(P<0.05).After treatment,there was no significant difference in HbA1c between the two groups(P>0.05).After treatment,the main symptom score,secondary symptom score,tongue and pulse score,and total score in both groups decreased compared with those before treatment;in the treatment group,the main symptom score,secondary symptom score,tongue and pulse score,and total score were(0.43±0.68),(0.90±0.61),(0.90±0.94)and(2.23±1.14)points,which were lower than(1.87±0.82),(1.73±0.98),(1.37±0.81)and(4.97±1.35)points in the control group;the difference was statistically significant(P<0.05).After treatment,there were no special abnormalities in electrocardiogram,blood routine,urine routine,stool routine,and no obvious drug toxicity and side effects.Conclusion Compound psyllium husk of medicine-food homologous is effective and safe in the treatment of type 2 diabetes mellitus,and can more effectively improve the clinical symptoms and HbA1c of patients.
基金项目
广东省中医药局中医药科研项目(粤中医函[2021]425号-20221398)
维普
万方数据