Analysis of clinical effect of NCPAP combined with caffeine citrate in the treatment of premature infants with apnea
Objective To analyze the clinical effect of nasal continuous positive airway pressure(NCPAP)combined with caffeine citrate in the treatment of premature infants with apnea.Methods 110 premature infants with apnea were divided into NCPAP treatment group(37 cases),caffeine treatment group(37 cases)and combined treatment group(36 cases)according to different treatment methods.NCPAP treatment group was treated with simple NCPAP,caffeine treatment group was treated with simple caffeine citrate,and the combined treatment group was treated with NCPAP and caffeine citrate.The curative effect,incidence of complications,clinical indicators,blood gas indicators,lung function indicators,and development of the three groups were compared.Results The total effective rate of the combined treatment group was 97.22% ,which was higher than 67.57% of the NCPAP group and 64.86% of the caffeine group,and the difference was statistically significant(P<0.05).The incidence of complications in the combined treatment group was 5.56% ,which was lower than 32.43% in the NCPAP treatment group and 35.14% in the caffeine treatment group,and the difference was statistically significant(P<0.05).The hospitalization time and duration of apnea in the combined treatment group were(18.20±3.86)d and(15.12±2.31)s/time,which were shorter than those in the NCPAP treatment group[(24.69±5.67)d and(19.46±3.67)s/time]and the caffeine treatment group[(24.78±5.58)d and(19.56±3.78)s/time];the combined treatment group had number of apnea of(1.15±0.14)times/d,which was less than(2.32±0.46)times/d in the NCPAP treatment group and(2.33±0.57)times/d in the caffeine treatment group;the difference was statistically significant(P<0.05).After treatment,the combined treatment group had lower arterial partial pressure of carbon dioxide of(40.27±3.30)mm Hg(1 mm Hg= 0.133 kPa),which was lower than(45.27±4.78)mm Hg in the NCPAP group and(45.38±4.89)mm Hg in the caffeine group;the combined treatment group had arterial partial pressure of oxygen of(78.32±6.87)mm Hg and pH of(7.42±0.05),which were higher than those of the NCPAP group[(69.85±5.46)mm Hg and(7.38±0.03)]and the caffeine group[(69.85±5.47)Hg and(7.39±0.04)];the difference was statistically significant(P<0.05).After treatment,the combined treatment group had motor score of(111.36±19.88)points and intelligence score of(113.68±18.53)points,which were higher than those in the NCPAP group[(96.71±20.86)and(98.62±17.58)]and the caffeine group[(96.82±20.98)and(98.71±17.47)].The difference was statistically significant(P<0.05).The combined treatment group had tidal volume of(8.58±1.68)ml/kg,ratio of the volume to peak expiratory flow and expiratory volume of(37.59±1.68)% ,ratio of the time to peak expiratiry flow and expiratory time of(36.38±1.55)% ,minute ventilation volume of(0.78±0.29)L/(min·kg),25% tidal volume expiratory flow rate of(36.88±1.36)ml/s,75% tidal volume expiratory flow rate of(36.78±1.49)ml/s,which were higher than those of the NCPAP group[(7.64±1.08)ml/kg,(33.06±1.51)% ,(33.56±1.37)% ,(0.47±0.16)L/(min·kg),(32.11±1.62)ml/s and(34.13±1.25)ml/s]and the caffeine group[(7.53±1.14)ml/kg,(33.04±1.42)% ,(33.57±1.48)% ,(0.49±0.27)L/(min·kg),(32.22±1.73)ml/s and(34.26±1.36)ml/s].The difference was statistically significant(P<0.05).Conclusion Implementing NCPAP combined with caffeine citrate therapy for premature infants with apnea can improve clinical indicators,promote development of children,reduce complications,and enhance treatment effect.It has high clinical application value.
NETL
NSTL
万方数据
