Analysis of application effect of early neurointerventional embolization in the treatment of elderly patients with ruptured intracranial aneurysms
Objective To explore the effect of early neurointerventional embolization in the treatment of elderly patients with ruptured intracranial aneurysms.Methods 28 elderly patients with ruptured intracranial aneurysms were randomly divided into an observation group(early neurointerventional embolization)and a control group(late neurointerventional embolization),with 14 patients in each group.The occurrence of complications and the levels of vascular endothelial function indicators[nitric oxide(NO),von Willebrands factor(vWF)and endothelin-1(ET-1)]were compared between the two groups.Results There was no significant difference in the incidence of cerebral edema,lower limb venous thrombosis,re-rupture hemorrhage and pulmonary infection between the two groups(P>0.05).Before surgery,NO,vWF and ET-1 in the observation group were(53.15±8.05)μmol/L,(117.85±25.42)ng/ml and(78.55±6.47)pg/ml,and those in the control group were(53.95±8.51)μmol/L,(118.25±26.12)ng/ml and(79.22±6.74)pg/ml.There was no significant difference between the two groups(P>0.05).After surgery,NO,vWF and ET-1 in the observation group were(72.15±10.25)μmol/L,(69.45±7.23)ng/ml and(43.41±7.20)pg/ml,and those in the control group were(88.15±9.66)μmol/L,(94.33±8.01)ng/ml and(56.23±6.81)pg/ml;the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Early neurointerventional embolization is effective and valuable in the treatment of ruptured intracranial aneurysms in the elderly.
Ruptured intracranial aneurysms in the elderlyVascular endothelial growth factorEarly neurointerventional embolizationComplicationsVascular endothelial function
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