Efficacy and safety analysis of levosimendan adjunctive to conventional Western medicine in the treatment of patients with severe pulmonary hypertension and right heart failure
Objective To explore the efficacy and safety of levosimendan adjunctive to conventional Western medicine in the treatment of patients with severe pulmonary hypertension and right heart failure.Methods 70 patients with severe pulmonary hypertension and right heart failure were divided into a control group and an observation group by random number table method,with 35 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with levosimendan based on the control group.The therapeutic effect,cardiac function indicators,brain natriuretic peptide level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the control group was 77.14% ,while the total effective rate of the observation group was 97.14% .The observation group was significantly higher than the control group(χ2=6.248,P=0.012<0.05).Before treatment,there was no significant difference in left ventricular ejection fraction(LVEF),right ventricular ejection fraction(RVEF)and B-type natriuretic peptide(BNP)levels between the two groups(P>0.05).After treatment,LVEF and RVEF increased and BNP decreased in both groups;the observation group had LVEF of(56.56±6.35)% and RVEF of(52.34±5.42)% ,which were significantly higher than(44.32±6.25)% and(42.36±5.26)% in the control group;the observation group had significantly lower BNP of(542.61±123.65)pg/ml than(853.62±185.33)pg/ml in the control group(P<0.05).The incidence of adverse reactions in the control group was 17.14% ,while that in the observation group was 20.00% .There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.095,P=0.759>0.05).Conclusion In the treatment of patients with severe pulmonary hypertension and right heart failure,the application of levosimendan can improve the therapeutic effect of patients,improve myocardial ischemia,and the use of medication is safe,which has clinical application value.
NETL
NSTL
万方数据
