Objective To observe the therapeutic effect of acupoint injection combined with nerve block on acute herpes zoster(AHZ).Methods 60 patients with acute herpes zoster were divided into group A and group B by random number table method,with 30 cases in each group.Group A was given basic drug treatment,and group B was given acupoint injection + nerve block treatment on the basis of group A.The visual analogue scale(VAS)score,herpes-related indicators(vesiculation time,crusting time,decrusting time)before and after treatment,clinical efficacy and incidence of postherpetic neuralgia(PHN)were compared between the two groups.Results The vesiculation time,crusting time,decrusting time of group B were(5.30±1.37),(9.50±1.94)and(15.03±1.97)d,which were shorter than(6.67±1.99),(11.47±2.30)and(18.53±3.58)d of group A,with a statistically significant difference(P<0.05).Before treatment,there was no significant difference in VAS score between the two groups(P>0.05).After treatment,VAS score in both groups was significantly lower than that before treatment;VAS score of(2.63±1.15)points in group B was lower than(3.67±0.80)points in group A;there was a statistically significant difference(P<0.05).After treatment,the clinical symptoms in both groups were improved,and the cure rate of 43.3% in group B was better than 16.7% in group A,with a statistically significant difference(P<0.05).1 month after treatment,the incidence of PHN in group B(20.0% )was significantly lower than that in group A(46.7% ),with a statistically significant difference(P<0.05).Conclusion Early intervention of acupoint injection combined with nerve block in AHZ can play a positive role in relieving pain and preventing the onset of postherpetic neuralgia without obvious adverse reactions,and is worthy of clinical recommendation.