Study on effect of Bifico combined with mesalazine and Kangfuxin solution in the treatment of ulcerative colitis
Objective To explore the clinical effect of live combined bifidobacterium,lactobacillus and enterococcus capsules(trade name:Bifico)combined with mesalazine and Kangfuxin solution in the treatment of ulcerative colitis.Methods A total of 89 patients with ulcerative colitis receiving drug therapy were divided into a control group(40 cases)and a study group(49 cases)according to random number table method.The control group was treated with mesalazine + Kangfuxin solution,and the study group was treated with Bifico based on the control group.Both groups were compared in terms of treatment effect,symptom resolution time,incidence of adverse reactions,immune function indicators(CD3+,CD4+/CD8+)level,serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)]level,symptom score,and quality of life score.Results The total effective rate of the study group was 97.96%,which was higher than 82.50%of the control group(P<0.05).The resolution time of diarrhea,abdominal pain and hematochezia in the study group were(3.29±0.81),(4.12±0.76)and(4.37±0.89)d,which were shorter than(4.32±0.97),(5.30±0.93)and(5.64±1.02)d in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,CD3+ and CD4+/CD8+ increased significantly in both groups compared with those before treatment;the study group had higher CD3+ of(45.39±2.87)%and CD4+/CD8+ of(2.10±0.48),which were higher than(41.18±2.91)%and(1.52±0.39)in the control group(P<0.05).After treatment,CRP,PCT and TNF-α decreased significantly in both groups compared with those before treatment;the study group had CRP of(5.89±1.06)mg/L,PCT of(0.46±0.15)ng/ml and TNF-α of(10.83±2.07)μg/L,which were lower than(7.02±1.27)mg/L,(0.69±0.23)ng/ml and(13.49±2.46)μg/L in the control group(P<0.05).After treatment,the scores of diarrhea,abdominal pain and hematochezia reduced significantly in both groups compared with those before treatment;the scores of diarrhea,abdominal pain and hematochezia in the study group were(1.17±0.39),(1.06±0.31)and(1.16±0.40)points,which were lower than(1.58±0.43),(1.52±0.48)and(1.61±0.45)points in the control group(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in both groups were significantly higher than those before treatment;the scores of physiology,psychology,environment and social relations in the study group were(89.75±6.48),(89.07±6.02),(90.14±6.15)and(89.96±6.27)points,which were higher than(82.93±6.85),(82.40±6.13),(83.27±6.30)and(83.14±6.54)points in the control group(P<0.05).Conclusion The combination of mesalazine,Kangfuxin solution and Bifico in the treatment of ulcerative colitis can enhance the curative effect,accelerate the relief of symptoms,regulate the immune function and reduce the inflammatory reaction.It is helpful to improve the quality of life,and the adverse reactions after the combination of drugs do not increase.So it has high safety.
Ulcerative colitisMesalazineKangfuxin solutionLive combined bifidobacterium,lactobacillus and enterococcus capsules
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