Comparison of practical effects of dexmedetomidine in single-port thoracoscopic radical resection of lung cancer
Objective To analyze the practical effects of dexmedetomidine in single-port thoracoscopic radical resection of lung cancer.Methods A total of 100 patients who underwent single-port thoracoscopic radical resection of lung cancer were selected and divided into the control group(without dexmedetomidine)and the experimental group(with dexmedetomidine)according to the intraoperative anesthesia,with 50 cases in each group.The control group was anesthetized with remifentanil combined with sevoflurane,while the experimental group was anesthetized with dexmedetomidine and remifentanil combined with sevoflurane.The variations of blood pressure and heart rate at 11 time points from preoperative to postoperative,recovery conditions and the changes of fasting blood glucose before and after surgery were compared between the two groups.The occurrence of complications and the use of additional drugs in the two groups were observed.Results a.Compared with the day before surgery(T1)of the same group,the systolic blood pressure before anesthesia(T2)was significantly increased for the two groups(P<0.05).b.On the first day after surgery(T11),the diastolic blood pressure of the two groups of patients was lower than that of this group at T1(P<0.05).c.At 60 min after anesthesia(T4),the heart rate of the patients in the experimental group was lower than that in the control group(P<0.05).d.There were no significant differences in extubation time,recovery time after extubation and total recovery time between the two groups(P>0.05).The Steward score of both groups reached 6 points in the post-anesthesia care unit(PACU),and the patients were safely returned to the general ward.e.There were no significant differences in the changes of fasting blood glucose before and after surgery between the two groups(P>0.05).The fasting blood glucose after surgery in both groups was higher than that before surgery(P<0.05).f.There were no serious complications during recovery in PACU in both groups after surgery,and there was no case that PACU stayed for more than 2 hours.Conclusion The application of dexmedetomidine combined with remifentanil and sevoflurane anesthesia in single-port thoracoscopic radical resection of lung cancer can reduce the heart rate of patients during the operations,and there is no significant difference in the other circulation indications,the quality of anesthesia resuscitation and the postoperative blood glucose is significantly higher than that before surgery,but there is no significant difference with remifentanil combined sevoflurane anesthesia.
DexmedetomidineSingle-port thoracoscopic radical resection of lung cancerStress responseHemodynamic changesQuality of anesthesia resuscitation
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