Efficacy and safety analysis of mild hypothermia combined with enteral nutrition in the treatment of children with central nervous system infection
Objective To compare the efficacy and safety of whole-body mild hypothermia and selective head mild hypothermia combined with enteral nutrition in the treatment of children with central nervous system infection.Methods The clinical data of 37 children with central nervous system infection were retrospectively analyzed,and they were divided into an observation group(19 cases)and a control group(18 cases).Both groups were treated with enteral nutrition.On this basis,the observation group was treated with whole-body mild hypothermia,and the control group was treated with selective head mild hypothermia.The time of fever reduction,the time of convulsion disappearance,the intensive care unit length of stay,the occurrence of adverse reactions,the laboratory indicators and their difference before and after treatment between the two groups were compared.Results The time of fever reduction,the time of convulsion disappearance and the intensive care unit length of stay in the observation group were(9.79±8.46)h,(4.79±4.97)d and(11.53±7.90)d,and those in the control group were(9.00±6.11)h,(6.61±5.10)d and(12.06±5.44)d.There was no significant difference between the two groups(P>0.05).The levels of hypersensitive C-reactive protein(hs-CRP),blood glucose,blood lactic acid,cerebrospinal fluid protein and cerebrospinal fluid glucose after 3 d of treatment were lower than those at admission,with statistically significant difference(P<0.05).There was no statistical significance in the levels of hypersensitive C-reactive protein,blood glucose,blood lactic acid,cerebrospinal fluid protein and cerebrospinal fluid glucose and their differences before and after treatment between the two groups(P>0.05).The incidence of diarrhea and abdominal distension in the observation group were 57.89%and 63.16%,which were higher than 22.22%and 27.78%in the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of vomiting between the two groups(P>0.05).Conclusion Both selective head mild hypothermia therapy and whole-body mild hypothermia combined with enteral nutrition have significant effects in the treatment of children with central nervous system infection,but there are no significant differences in time of fever reduction,time of convulsion disappearance and intensive care unit length of stay.Compared with whole-body mild hypothermia,selective head mild hypothermia has better safety in reducing the incidence of diarrhea and abdominal distension in children.
Whole-body mild hypothermiaSelective head mild hypothermiaEnteral nutritionCentral nervous system infection
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