Association between pre-pregnancy body mass index and renal function and pregnancy outcomes
Objective To analyze the data of pre-pregnancy body mass index(BMI)of single pregnant women,renal function before laboring and pregnancy outcome,to discuss the association between pre-pregnancy BMI and renal dysfunction and pregnancy outcomes.Methods The data of 1218 cases of singleton pregnancy with routine perinatal care and delivery were retrospectively analyzed,and divided into underweight group(<18.5 kg/m2,176 cases),normal weight group(18.5-24.9 kg/m2,670 cases),overweight group(25.0-27.9 kg/m2,266 cases)and obesity group(≥28.0 kg/m2,106 cases)according to different pre-pregnancy BMI.Among them,806 pregnant women with severe preeclampsia were divided into the early-onset group(442 cases)and the late-onset group(364 cases)with 34 weeks as the boundary.The renal function-related indexes and pregnancy outcomes of pregnant women in each group were compared.Results Pre-pregnancy BMI of ealy-onset group was(23.32±4.30)kg/m2,which was higher than(22.44±3.74)kg/m2 of the late-onset group,and the difference was statistically significant(P<0.05).There was no significant difference in renal function indexes between normal weight group and underweight group(P>0.05).The renal function indexes in the normal weight group were lower than those in the overweight group and the obesity group,and the difference was statistically significant(P<0.05).The uric acid,β2 microglobulin and α1 microglobulin in the overweight group were lower than those in the obesity group,and the difference was statistically significant(P<0.05).There were no significant differences in gestational weeks of onset and gestational weeks of delivery among all groups(P>0.05).The neonatal weight and 1 min Apgar score in the normal weight group were higher than those in the underweight group,the overweight group and the obesity group,and the difference was statistically significant(P<0.05).Conclusion Pre-pregnancy BMI has a certain effect on renal function and pregnancy outcome of singleton pregnancy.Keeping pre-pregnancy BMI in the normal range can help maintain normal kidney function and improve pregnancy outcomes.
Body mass indexPreeclampsiaRenal functionPregnancy outcomes
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