Diagnostic value of serum irisin levels in hypertensive patients with severe obstructive sleep apnea syndrome
Objective To observe the diagnostic value of serum irisin levels in hypertensive patients with severe obstructive sleep apnea syndrome(OSAS).Methods A total of 156 hypertensive patients were selected.According to apnea hypopnea index(AHI),the patients were divided into severe OSAS group(79 cases)and non-severe OSAS group(77 cases).The baseline data,polysomnography(PSG)and ambulatory blood pressure monitoring(ABPM)were collected and serum irisin levels were measured.The baseline data and serum irisin levels of the two groups were compared,and the correlation between serum irisin levels and various indicators,as well as receiver operating characteristic(ROC)curve of serum irisin levels were analyzed.Results There were no significant differences in body mass index(BMI),office systolic blood pressure(SBP),office diastolic blood pressure(DBP)and 24-h mean SBP and DBP between the two groups(P>0.05).The age,male proportion,abdominal circumference,neck circumference,AHI in severe OSAS group were higher than those in non-severe OSAS group;the severe OSAS group had lower lowest oxygen saturation(LSpO2)and mean blood oxygen saturation(MSpO2)than those in non-severe OSAS group;the differences were statistically significant(P<0.05).The median serum irisin level in 156 patients was 25.17 ng/ml,the median serum irisin level in the severe OSAS group was 14.94(4.45,28.93)ng/ml,and the median serum irisin level in the non-severe OSAS group was 42.34(21.93,74.31)ng/ml.The median serum irisin level was significantly different between the two groups(P<0.001).In 156 hypertensive patients,serum irisin level was negatively correlated with age and AHI(r=-0.175,-0.359;P=0.029,0.000<0.05),and was positively correlated with MSpO2(r=0.188,P=0.020<0.05).ROC curve analysis showed that the critical value of serum irisin concentration was 38.07 ng/ml,the area under the curve(AUC)was 0.761,the sensitivity was 86.08%(68/79),the specificity was 61.04%(47/77),the positive predictive value was 69.39%(68/98),and the negative predictive value was 81.03%(47/58).Conclusion In hypertensive population,the serum irisin concentration of OSAS patients is negatively correlated with the severity of OSAS.Serum irisin level can be used as a diagnostic index for severe OSAS patients.
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