Effect of treatment with tirofiban on levels of Lp-PLA2 and Galectin-1 in patients with acute cerebral infarction
Objective To observe the changes of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and Galectin-1 in patients with acute cerebral infarction(ACI)after intravenous tirofiban.Methods 48 cases of ACI patients treated with intravenous tirofiban in the Department of Neurology were selected as the observation group,and 46 healthy subjects were selected as the control group.Venous blood was extracted from the control group on admission,and from the observation group before treatment and on day 1,day 7 and day 30 after intravenous tirofiban.Serum Lp-PLA2 and Galectin-1 levels were compared between the two groups and before and after treatment in the observation group,as well as modified Rankin Scale(mRS)scores before and after treatment in observation group.Results Serum Lp-PLA2 levels in the observation group were(301.16±1.24),(264.25±0.98),(198.36±1.02)and(251.48±1.13)ng/ml before treatment and on the 1st,7th and 30th days of treatment,which was higher than(148.25±1.47)ng/ml in the control group(P<0.05).After tirofiban treatment,the serum Lp-PLA2 level in the observation group gradually decreased compared with that before treatment,but the serum Lp-PLA2 level on the 30th day of treatment was higher than that on the 7th day of treatment(P<0.05).Serum Galectin-1 levels in the observation group were(314.00±93.62),(203.00±85.41),(145.00±81.34)and(198.00±83.46)pg/ml before treatment and on the 1st,7th and 30th days of treatment,which was higher than(96.00±42.33)pg/ml in the control group(P<0.05).After tirofiban treatment,serum Galectin-1 level in the observation group was gradually decreased compared with that before treatment,but the serum Galectin-1 level on the 30th day of treatment was increased compared with that on the 7th day of treatment(P<0.05).mRS Score of the observation group was(3.04±0.43)points before treatment,and(1.05±0.31)points after 90 d of treatment,which was lower than that before treatment,and the difference was statistically significant(P<0.05).Conclusion Intravenous tirofiban can decrease the serum levels of Lp-PLA2 and Galectin-1 and promote the recovery of neurological function in patients with ACI.
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