高流量湿化联合呼吸兴奋剂治疗AECOPD合并Ⅱ型呼吸衰竭的疗效观察
Efficacy observation of high flow humidification combined with respiratory stimulants in the treatment of AECOPD with type Ⅱ respiratory failure
陈亚宽 1张海清 1林杰 1吴卓荣1
作者信息
摘要
目的 探讨高流量湿化联合呼吸兴奋剂治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的疗效.方法 78 例AECOPD合并Ⅱ型呼吸衰竭患者,按随机数字表法分为对照组与观察组,每组 39 例.对照组使用BiPAP无创呼吸机通气治疗,观察组使用高流量湿化联合呼吸兴奋剂治疗.对比两组的临床疗效、血气分析指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血氧饱和度(SaO2)、氧合指数(OI)]、住院时间、心率(HR)及呼吸频率(RR).结果 观察组治疗总有效率为 94.87%,明显高于对照组的 74.36%(P<0.05).治疗后,观察组PaO2(85.37±7.29)mm Hg(1 mm Hg= 0.133 kPa)、OI(296.83±31.95)mm Hg、SaO2(92.54±4.18)%高于对照组的(76.41±7.90)mm Hg、(257.48±29.63)mm Hg、(85.73±4.49)%,PaCO2(39.54±5.47)mm Hg低于对照组的(50.72±6.31)mm Hg(P<0.05).治疗后,观察组HR(70.36±5.41)次/min、RR(18.90±1.24)次/min均低于对照组的(82.94±7.52)、(22.97±2.01)次/min(P<0.05);观察组住院时间(7.21±1.75)d短于对照组的(13.68±2.49)d(P<0.05).结论 与BiPAP无创呼吸机通气治疗相比,高流量湿化联合呼吸兴奋剂治疗AECOPD合并Ⅱ型呼吸衰竭的疗效显著,能有效改善血气指标,提升肺通气功能,缩短住院时间.
Abstract
Objective To explore the efficacy of high flow humidification combined with respiratory stimulants in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with typeⅡ respiratory failure.Methods 78 patients with AECOPD and type Ⅱ respiratory failure were divided into a control group and an observation group according to random number table method,with 39 cases in each group.The control group was treated with BiPAP non-invasive ventilator,and the observation group was treated with high flow humidification and respiratory stimulants.Both groups were compared in terms of clinical efficacy,blood gas analysis indicators[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2),oxygenation index(OI)],length of hospital stay,heart rate(HR)and respiratory rate(RR).Results The total effective rate of the observation group was 94.87%,which was significantly higher than 74.36%of the control group(P<0.05).After treatment,the observation group PaO2 of(85.37±7.29)mm Hg(1 mm Hg =0.133 kPa),OI of(296.83±31.95)mm Hg,SaO2 of(92.54±4.18)%,which were higher than(76.41±7.90)mm Hg,(257.48±29.63)mm Hg,(85.73±4.49)%in the control group;the observation group had lower PaCO2 of(39.54±5.47)than(50.72±6.31)mm Hg in the control group(P<0.05).After treatment,the observation group had HR of(70.36±5.41)beats/min and RR of(18.90±1.24)times/min,which were lower than(82.94±7.52)beats/min and(22.97±2.01)times/min in the control group(P<0.05).The length of hospital stay in the observation group was(7.21±1.75)d,which was shorter than(13.68±2.49)d in the control group(P<0.05).Conclusion Compared with BiPAP non-invasive ventilator ventilation,high-flow humidification combined with respiratory stimulants has significant efficacy in the treatment of AECOPD with type Ⅱ respiratory failure,which can effectively improve the blood gas indicators,enhance the lung ventilation function and shorten the length of hospital stay.
关键词
慢性阻塞性肺疾病急性加重期/Ⅱ型呼吸衰竭/高流量湿化/呼吸兴奋剂/疗效Key words
Acute exacerbation of chronic obstructive pulmonary disease/Type Ⅱ respiratory failure/High flow humidification/Respiratory stimulants/Efficacy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据