Effect analysis of octreotide combined with thrombin in the treatment of acute gastrointestinal bleeding
Objective To analyze the effect of octreotide combined with thrombin in the treatment of acute gastrointestinal bleeding.Methods 80 patients with acute gastrointestinal bleeding were randomly divided into a control group and an experimental group,with 40 cases in each group.The control group received thrombin treatment,and the experimental group received octreotide and thrombin combined treatment.Both groups were compared in terms of clinical efficacy,blood routine indicators[hemoglobin(Hb),platelet count(PLT),red blood cell count(RBC),white blood cell count(WBC)],oxidative stress indexes,symptom improvement time,recovery time of laboratory indicators,hospital stay and incidence of adverse reactions.Results The total effective rate of 95.00%in the experimental group was significantly higher than 77.50%in the control group(P<0.05).After treatment,the experimental group had Hb of(115.68±12.76)g/L,PLT of(146.44±14.85)×109/L,RBC of(5.79±0.55)×1012/L,which were significantly higher than(109.33±15.44)g/L,(134.44±14.25)×109/L,(4.85±0.42)×1012/L in the control group;the experimental group had significantly lower WBC of(8.72±1.41)×109/L than(9.56±1.82)×109/L in the control group(P<0.05).In the experimental group,the improvement time of abdominal distension and abdominal pain was(2.33±0.80)d,the recovery time of blood oxygen was(4.24±1.01)d,the recovery time of blood amylase was(5.60±1.40)d,and the hospital stay was(12.60±3.11)d,which were significantly shorter than(3.49±1.15),(5.33±1.61),(7.20±1.84),and(17.69±4.80)d in the control group(P<0.05).Compared with the control group,the levels of superoxide dismutase and glutathione peroxidase in the experimental groups after treatment were significantly higher,and the levels of lipid hydrogen peroxide and malondialdehyde were significantly lower(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of octreotide and thrombin in patients with acute gastrointestinal bleeding is effective,which not only ensures the therapeutic effect and safety,but also optimizes the blood routine indicators and oxidative stress indicators,and shortens the treatment time,which is worth promoting.
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