Value analysis of low-dose aspirin in prevention of preeclampsia in high-risk pregnant women
Objective To explore the clinical value of low-dose aspirin in prevention of preeclampsia in high-risk pregnant women.Methods 70 high-risk pregnant women were divided into a control group and an observation by digital lottery,with 35 cases in each group.All pregnant women were routinely monitored,and pregnant women in the observation group were treated with low-dose aspirin.The delivery outcome,preeclampsia occurrence,inflammation index[platelet-to-lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR)]level and coagulation function index[activated partial thromboplastin time(APTT),thrombin time(TT)]level were compared between the two groups.Results The incidence of preterm delivery and cesarean section in the observation group were 14.29%and 11.43%,which were significantly lower than 51.43%and 54.29%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of postpartum hemorrhage between the two groups(P>0.05).The incidence of early-onset preeclampsia,late-onset preeclampsia and total incidence of preeclampsia in the observation group were 5.71%,11.43%and 17.14%,which were significantly lower than 25.71%,34.29%and 60.00%in the control group,with statistical significance(P<0.05).At 36 weeks of gestation,the observation group had PLR of(116.49±9.22)and NLR of(4.24±0.33),which were significantly lower than(124.07±11.76)and(4.51±0.55)in the control group;the observation group had PT of(11.90±0.56)s and APTT of(29.98±0.49)s,which were significantly longer than(9.15±0.20)and(24.14±0.33)s in the control group;the difference was statistically significant(P<0.05).Conclusion Taking low-dose aspirin in high-risk pregnant women can effectively prevent preeclampsia.
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