Efficacy of sufentanil combined with flurbiprofen axetil in patients with patient-controlled intravenous analgesia after functional endoscopic sinus surgery
Objective To explore the effect of sufentanil combined with flurbiprofen axetil in patients with patient-controlled intravenous analgesia(PCIA)after functional endoscopic sinus surgery(FESS).Methods A total of 78 FESS patients were selected as the study subjects and divided into a control group and an observation group according to random number table method,with 39 cases in each group.The control group received sufentanil for PCIA,and the observation group received sufentanil combined with flurbiprofen axetil for PCIA.The analgesic effect,sedation effect,stress reaction,use of PCIA and incidence of adverse reactions were compared between the two groups.Results At 3,6 and 12 h after surgery,the observation group had visual analogue scale(VAS)scores of(3.58±0.42),(2.39±0.32)and(1.85±0.24)points,sedation-agitation scale(SAS)scores of(4.24±0.45),(3.46±0.37)and(2.83±0.22)points,which were lower than(4.12±0.51),(3.08±0.41),(2.31±0.29)points and(4.95±0.59),(4.01±0.38),(3.39±0.35)points in the control group(P<0.05).At 24 h after surgery,the levels of cortisol(COR),norepinephrine(NE)and adrenocorticotrophic hormone(ACTH)in the observation group were(181.62±18.74)μg/L,(230.14±25.59)ng/L and(10.12±1.53)ng/L,which were lower than(204.36±19.75)μg/L,(251.52±26.43)ng/L and(12.96±1.62)ng/L in the control group(P<0.05).The number of PCIA compression and the actual effective times of administration in the observation group were(7.41±1.12)and(4.15±0.67)times/24 h,which were less than(9.69±1.27)and(5.25±1.05)times/24 h in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sufentanil combined with flurbiprofen axetil has high application value in postoperative PCIA in patients with FESS,which can improve the analgesic and sedative effects of patients,reduce the stress response of the body,reduce the number of PCIA compression,and is safe and reliable.
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