Study on the therapeutic effect of cyclosporin A for refractory lupus nephritis
Objective To explore the therapeutic effect of cyclosporin A for refractory lupus nephritis.Methods 120 patients with refractory lupus nephritis were selected as observation subjects.According to different treatment plans,they were divided into the reference group(60 cases)and the study group(60 cases).The reference group conducted conventional hormone therapy,and the study group added cyclosporin A to the conventional hormone therapy.The therapeutic effect and incidence of adverse reactions,and renal function indicators,immune function indicators,T-lymphocyte subsets,and inflammatory factors before and after treatment of the two groups were compared.Results The total effective rate of the study group was 95.00%,which was higher than 81.67%of the reference group(P<0.05).After treatment,the microalbuminuria(MAU),blood β2 microglobulin,urinary β2 microglobulin and 24 h urinary protein decreased in both groups compared with those before treatment;MAU in the study group was(65.18±10.33)mg/L,the blood β2 microglobulin was(2.41±0.21)mg/L,the urinary β2 microglobulin was(0.28±0.07)mg/L,and the 24 h urinary protein was(0.54±0.11)g/24 h,which were lower than(125.39±10.87)mg/L,(3.72±0.23)mg/L,(0.53±0.06)mg/L,and(0.95±0.13)g/24 h in the reference group(P<0.05).After treatment,the immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG),CD3+,and CD4+/CD8+ increased in both groups compared with those before treatment;the study group had CD3+ of(60.13±4.24)%,CD4+/CD8+ of(1.80±0.11),IgA of(2.68±0.35)g/L,IgM of(1.45±0.19)g/L,and IgG of(15.54±1.32)g/L,which were higher than(43.21±3.45)%,(1.43±0.13),(1.81±0.32)g/L,(1.09±0.15)g/L,and(10.13±1.46)g/L in the reference group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-8(IL-8),and interleukin-6(IL-6)in both groups decreased compared with those before treatment;the study group had TNF-α of(21.12±3.24)ng/L,hs-CRP of(5.16±1.09)mg/L,IL-8 of(20.11±3.05)μg/L,and IL-6 of(11.75±4.02)ng/L,which were lower than(28.31±4.05)ng/L,(8.12±1.05)mg/L,(25.24±3.06)μg/L,and(20.12±4.25)ng/L in the control group(P<0.05).The incidence of adverse reactions in the study group was 8.33%,and there was no significant difference compared to 10.00%in the control group(P>0.05).Conclusion Cyclosporine A has significant effect in the treatment of refractory lupus nephritis,and can improve the therapeutic effect,renal function,immune function and inflammatory reactions of patients.
Cyclosporin ARefractory lupus nephritisImmune functionRenal function
NETL
NSTL
万方数据
维普
