Effect evaluation of non-invasive positive pressure ventilation in emergency treatment of severe bronchial asthma complicated with respiratory failure
Objective To observe the effect of non-invasive positive pressure ventilation in emergency treatment of severe bronchial asthma complicated with respiratory failure.Methods 62 patients with severe bronchial asthma complicated with respiratory failure were divided into a control group and an experimental group according to the principle of double-blind randomization,with 31 cases in each group.Children in both groups were given conventional treatment,on this basis,the control group was treated with invasive positive pressure ventilation,and the experimental group was treated with non-invasive positive pressure ventilation.The basic vital signs,inflammatory markers,blood gas analysis indicators and complications were compared between the two groups.Results After 24 h of treatment,the experimental group had lower heart rate of(96.65±7.14)beats/min than(112.32±7.11)beats/min in the control group;the experimental group had systolic blood pressure of(125.65±4.67)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure of(85.45±3.54)mm Hg,which were higher than(120.54±4.69)and(73.16±3.51)mm Hg in the control group(P<0.05).After 24 h of treatment,the C-reactive protein,interleukin-6 and interleukin-17 in the experimental group were(8.54±1.43)mg/L,(114.54±24.65)pg/ml and(3.54±0.15)ng/L,which were lower than(15.24±1.47)mg/L,(148.65±24.61)pg/ml and(5.24±0.11)ng/L in the control group(P<0.05).After 24 h of treatment,the experimental group had arterial partial pressure of oxygen of(80.14±3.03)mm Hg and the arterial oxygen saturation of(94.56±1.56)%,which were higher than(73.26±3.06)mm Hg and(87.21±1.52)%in the control group;the experimental group had lower arterial partial pressure of carbon dioxide of(40.24±3.61)mm Hg than(46.18±3.64)mm Hg in the control group(P<0.05).After 24 h of treatment,the forced expiratory volume in one second,the ratio of forced expiratory volume in one second to forced vital capacity,and the minute ventilation volume were(1265.54±21.31)ml,(82.56±5.71)%,and(7.73±0.62)L,which were higher than(1043.26±21.27)ml,(75.61±5.72)%,and(5.25±0.59)L in the control group(P<0.05).The complication rate of 9.68%in the experimental group was lower than 32.26%in the control group(P<0.05).Conclusion The application of non-invasive positive pressure ventilation in the emergency treatment of severe bronchial asthma complicated with respiratory failure can significantly improve the clinical effect.
NETL
NSTL
万方数据
维普
