Study on clinical value of CVP monitoring and critical care ultrasound guided fluid resuscitation in the treatment of septic shock
Objective To explore the clinical value of central venous pressure(CVP)monitoring and critical care ultrasound guided fluid resuscitation in the treatment of septic shock.Methods A total of 80 patients with septic shock were selected as the subjects of this study.Based on the number of admission sequences of patients,80 patients were randomly divided into a control group and an observation group by random numerical grouping method,with 40 cases in each group.The control group received CVP monitoring combined with routine fluid resuscitation,and the observation group received CVP monitoring combined with critical care ultrasound guided fluid resuscitation.Comparison was made on hemodynamic indexes[mean arterial pressure(MAP),CVP,cardiac output(CO),oxygenation index(OI)]and immune function indexes[CD4+,CD8+,interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]before and after treatment.Results After treatment,the observation group had MAP of(81.97±10.62)mm Hg(1 mm Hg=0.133 kPa),CVP of(12.98±3.94)cm H2O(1 cm H2O=0.098 kPa),CO of(2.36±0.38)L/min,and OI of(235.88±24.91)mm Hg,which were higher than(76.19±9.13)mm Hg,(11.02±2.29)cm H2O,(2.19±0.28)L/min,and(194.53±23.91)mm Hg of the control group(P<0.05).After treatment,CD4+ in the observation group was(43.02±4.09)%,CD8+ was(28.30±5.33)%,IL-6 was(81.72±16.33)pg/ml,IL-8 was(30.67±8.42)pg/ml and TNF-α was(151.55±18.86)pg/ml.After treatment,CD4+ in the control group was(37.76±4.29)%,CD8+ was(34.11±3.16)%,IL-6 was(106.89±19.83)pg/ml,IL-8 was(38.50±9.88)pg/ml and TNF-α was(256.09±26.63)pg/ml.After treatment,the observation group had higher CD4+ than that in the control group;and CD8+,IL-6,IL-8 and TNF-α in the observation group were lower than those in the control group(P<0.05).Conclusion CVP monitoring combined with critical care ultrasound guided fluid resuscitation in patients with septic shock can effectively improve the hemodynamic indexes and immune function of patients,which is worthy of promotion and application.
Central venous pressure monitoringCritical care ultrasoundFluid resuscitationSeptic shockHemodynamic indicatorsImmune function
NETL
NSTL
万方数据
维普
