Study on clinical value of serum biochemistry and immunoglobulin M detection in Kawasaki's disease with liver function impairment
Objective To analyze the value of serum biochemistry and immunoglobulin(Ig)M detection in the detection of Kawasaki's disease(KD)with liver function impairment.Methods 66 children with KD were selected and divided into an observation group(13 cases with abnormal liver function indicators)and a control group(53 cases with normal liver function indicators)based on whether the liver function indicators were normal.Detection and comparison were made on blood routine and inflammatory markers[white blood cell count(WBC),polymorphonuclear neutrophils(PMN),hemoglobin(Hb),platelet count(PLT),procalcitonin(PCT),C-reactive protein(CRP),red blood cell count(RBC)],liver function indexes[total bilirubin(TBIL),total bile acid,gamma-glutamyl transpeptidase(GGT),aspartate transaminase(AST),alanine aminotrasferase(ALT)],cardiac function indexes[hydroxybutyrate dehydrogenase(HBDH),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB),creatine kinase(CK)],humoral immune markers(IgM,IgG,IgA,IgE)between the two groups.Results The levels of PCT,CRP and PMN in the observation group were higher than those in the control group,and there were significant differences between the two groups(P<0.05).There were no differences in PLT,Hb,RBC and WBC between the two groups(P>0.05).The observation group had TBIL of(16±14)μmol/L,total bile acid of(76±74)μmol/L,GGT of(109±60)U/L,AST of(108±77)U/L,and ALT of(113±70)U/L,which were higher than(6±3)μmol/L,(19±29)μmol/L,(29±36)U/L,(37±15)U/L,and(25±23)U/L in the control group.There were significant differences between the two groups(P<0.05).The observation group had HBDH of(281±83)U/L,LDH of(400.0±135.0)U/L,CK-MB of(41.0±26.0)U/L,and CK of(73±60)U/L,and those in the control group were(226±130),(340.1±118.9),(34.0±29.1),and(69±42)U/L;there was no significant differences between the two groups(P>0.05).The observation group had IgE of(493±54)ng/ml,IgG of(9±6)g/L,and IgA of(1±0)g/L,and those in the control group were(523±62)ng/ml,(10±5)g/L,and(1±0)g/L.There was no significant differences between the two groups(P>0.05).The observation group had lower IgM of(0.9±0.3)g/L than(1.2±0.2)g/L in the control group(P<0.05).Conclusion The levels of PCT,PMN,and CRP in children with KD combined with liver function impairment increase,but the serum IgM levels decrease,indicating that KD can cause liver damage and thus affect humoral immunity.It is of great significance in diagnosis,monitoring,and selecting treatment measures.
NETL
NSTL
万方数据
维普
