Changes of serum ECM1,MMP-9 and VEGF levels in patients with hepatocellular carcinoma and their significance
Objective To investigate the changes of serum extracellular matrix protein 1(ECM1),matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)levels in patients with hepatocellular carcinoma(HCC)and their significance.Methods A total of 60 patients with hepatocellular carcinoma were retrospectively analyzed.Patients were mainly treated with apatinib mesylate,and can also be treated by transcatheter arterial chemoembolization with GEMOX regimen if necessary.The serum ECM1,VEGF and MMP-9 levels were measured by enzyme linked immunosorbent assay before and after treatment.The levels of ECM1,MMP-9 and VEGF were compared before and after treatment.The levels of ECM1,MMP-9 and VEGF were compared among patients with different clinicopathologic features(age,gender,vascular invasion,lymph node metastasis,TNM stage,Edmondson stage and tumor diameter).Results After treatment,the levels of ECM1,MMP-9 and VEGF were(135.23±44.58)pg/ml,(421.25±87.56)μg/L and(657.56±54.56)pg/ml,which were lower than(215.56±30.80)pg/ml,(499.56±30.56)μg/L and(798.02±50.79)pg/ml before treatment(P<0.05).There were no significant differences in the levels of ECM1,MMP-9 and VEGF among patients of different ages and genders(P>0.05).There were statistical significant differences in ECM1,MMP-9 and VEGF levels among patients with different vascular invasion,lymph node metastasis,TNM stage,Edmondson stage and tumor diameter(P<0.05).Conclusion The interaction of ECM1,MMP-9 and VEGF can promote the metastasis of liver cancer cells,and the health status of liver cells in patients can be understood according to the level.
Hepatocellular carcinomaExtracellular matrix protein 1Matrix metalloproteinase-9Vascular endothelial growth factor
NETL
NSTL
万方数据
维普
