Study on the safety of atorvastatin combined with clopidogrel in the treatment of cerebral thrombosis and the improvement of coagulation function
Objective To analyze the safety of atorvastatin combined with clopidogrel in the treatment of cerebral thrombosis and the improvement of coagulation function.Methods 100 patients with cerebral thrombosis were divided into a reference group and an experimental group according to the random numerical table,each with 50 cases.Both groups received conventional treatment.On this basis,the reference group was given atorvastatin treatment,and the experimental group was given atorvastatin combined with clopidogrel for treatment.Both groups were compared in terms of safety,coagulation function[D-dimer(D-D),fibrinogen(Fib),prothrombin time(PT),activated partial thromboplastin time(APTT)],hemorheology(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity),treatment effect,and occurrence of adverse events.Results The incidence of adverse reactions was 4.00%in the experimental group and 18.00%in reference group,and there was statistical difference(χ2=5.0051,P=0.0253<0.05).Before treatment,there were no statistical differences in D-D,Fib,PT and APTT between the two groups(P>0.05).After treatment,the experimental group had D-D of(151.26±23.17)ng/ml and Fib levels of(3.02±0.27)g/L,which were lower than(179.02±26.14)ng/ml and(3.95±0.38)g/L of the reference group;the experimental group had PT of(12.29±1.79)s and APTT of(35.33±2.16)s,which were longer than(11.68±1.15)and(32.37±2.09)s in the reference group;there was a statistical difference(P<0.05).Before treatment,there was no difference in whole blood low shear viscosity,whole blood high shear viscosity and plasma viscosity between the two groups(P>0.05).After treatment,the whole blood low shear viscosity,whole blood high shear viscosity and plasma viscosity in the experimental group were(4.51±0.63),(3.27±0.36)and(1.58±0.38)mPa·s,which were lower than(5.83±0.73),(4.15±0.68)and(2.16±0.52)mPa·s in the the reference group.There was a statistical difference(P<0.05).The total effective rate of 96.00%in the experimental group was significantly higher than 84.00%in the reference group,and there was a statistical difference(P<0.05).After follow-up,it was found that the incidence of adverse events in the experimental group was 6.00%,which was lower than 22.00%in the reference group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of cerebral thrombosis,atorvastatin combined with clopidogrel is a valuable scheme,which can effectively improve the coagulation function under the premise of ensuring the safety of medication,and is worthy of promotion.
AtorvastatinClopidogrelCerebral thrombosisSafetyCoagulation function
NETL
NSTL
万方数据
维普
