Clinical effect analysis of patients with chronic obstructive pulmonary disease treated with bronchodilator agent plus ICS
Objective To analyze the clinical effectiveness of bronchodilator agent plus inhaled corticosteroid(ICS)in the treatment of patients with chronic obstructive pulmonary disease.Methods 200 patients with chronic obstructive pulmonary disease were selected as the study subjects and divided into a study group and a control group by two-color sphere extraction method,with 100 cases in each group.The control group was treated with conventional therapy,and the study group was treated with bronchodilator agent plus ICS based on the control group.Both groups were compared in terms of clinical indicators,pulmonary function indicators[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)],inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)],therapeutic effect,and incidence of adverse reactions.Results In the study group,the hospitalization time was(15.55±2.12)d,the cough length was(4.25±3.22)d,and the lung wheezing time was(3.50±1.08)d;in the control group,the hospitalization time was(25.40±2.65)d,the cough length was(6.75±1.06)d,and the lung wheezing time was(6.00±1.00)d.The hospitalization time,cough length and the lung wheezing time of the study group were shorter than those of the control group,and there was a significant difference(P<0.05).After treatment,PEF,FVC and FEV1 of the study group were significantly higher than those of the control group,and there was a significant difference(P<0.05).After treatment,CRP and PCT in the study group were(9.12±0.43)mg/L and(0.18±0.04)ng/ml,and those in the control group were(15.80±2.08)mg/L and(1.23±0.11)ng/ml;CRP and PCT in the study group were lower.There was a significant difference(P<0.05).The total effective rate of the study group was 98.00%(98/100),and that of the control group was 73.00%(73/100).The total effective rate of the study group was higher than that of the control group,and there was a significant difference(P<0.05).The incidence of adverse reactions was 0.20%(2/100)in the study group and 11.00%(11/100)in the control group.The incidence of adverse reactions in the study group was lower than that in the control group,and there was a significant difference(P<0.05).Conclusion Bronchodilator agent plus ICS can effectively improve the condition of chronic obstructive pulmonary disease patients,reduce the inflammatory response of patients,delay the progression of the disease,and improve the quality of life of patients,which is worthy of promotion and application.
NETL
NSTL
万方数据
维普
