Analysis of curative effect of dual therapy with lansoprazole and amoxicillin for the treatment of Helicobacter pylori-associated chronic gastritis
Objective To explore the clinical efficacy of dual therapy with lansoprazole and amoxicillin for the treatment of patients with Helicobacter pylori(Hp)-associated chronic gastritis.Methods 120 patients with Hp-associated chronic gastritis were divided into a reference group and a study group by coin tossing method,with 60 cases in each group.The reference group was treated with lansoprazole,and the study group was treated with dual therapy with lansoprazole and amoxicillin.Comparison was made on levels of inflammatory factors[interleukin-8(IL-8),interleukin-6(IL-6),tumor cell necrosis factor-α(TNF-α)],Hp clearance rate,recurrence rate,and incidence of adverse reactions(bitter mouth,gastrointestinal reactions,skin reactions,and dizziness)between the two groups.Results After treatment,the levels of IL-8,IL-6 and TNF-α in the study group were(7.63±1.32)ng/L,(16.39±3.22)ng/L and(1.21±0.42)μg/ml,which were significantly lower than(9.39±1.55)ng/L,(34.52±13.49)ng/L and(1.85±0.53)μg/ml in the reference group(P<0.05).The study group had higher Hp clearance rate of 98.33%(59/60)than 81.67%(49/60)in the reference group,and lower recurrence rate of 1.67%(1/60)than 13.33%(8/60)in the reference group(P<0.05).The incidence of adverse reactions in the study group was 5.00%,which had no statistical significance compared with 3.33%in the reference group(P>0.05).Conclusion The clinical application of dual therapy with lansoprazole and amoxicillin has significant efficacy for patients with Hp-associated chronic gastritis,and can significantly improve the level of inflammatory factors in patients,increase the Hp clearance rate,reduce the recurrence rate,and will not lead to increased mouth pain,gastrointestinal reactions,skin reactions and dizziness.
NETL
NSTL
万方数据
维普
