Clinical observation of Danshi tablet combined with cefazolin sodium in the treatment of chronic cholecystitis
Objective To observe the clinical effect of Danshi tablet combined with cefazolin sodium in the treatment of chronic cholecystitis.Methods 90 patients with chronic cholecystitis were studied and divided into a conventional group(admission from January 2020 to June 2021)and an experimental group(admission from July 2021 to December 2022)according to their different admission time,with 45 cases in each group.The conventional group was treated with intravenous infusion of cefazolin sodium,and the experimental group was treated with Danshi tablet on the basis of the conventional group.Comparison was made on clinical symptom scores(nausea and vomiting,greasy-aversion,gallbladder pain,abdominal distension)and MC Gill pain score[visual analogue scale(VAS),pain rating index(PRI),present pain intensity(PPI)],inflammatory indicators[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],liver and bile function indicators[alanine aminotrasferase(ALT),aspartate transaminase(AST),total bilirubin(TBIL)]before and after treatment,and clinical therapeutic effect between the two groups.Results After treatment,the conventional group had nausea and vomiting score of(2.40±0.15)points,greasy-aversion score of(1.45±0.13)points,gallbladder pain score of(2.77±0.18)points,and abdominal distension score of(1.94±0.07)points;the experimental group had nausea and vomiting score of(1.20±0.07)points,greasy-aversion score of(0.52±0.10)points,gallbladder pain score of(1.13±0.11)points,and abdominal distension score of(0.63±0.04)points.The scores of nausea and vomiting,greasy-aversion,gallbladder pain and abdominal distension in the experimental group were lower than those in the conventional group(P<0.05).After treatment,the conventional group had VAS score of(3.30±0.40)points,PRI score of(1.14±0.10)points,PPI score of(2.66±0.14)points;the experimental group had VAS score of(1.12±0.30)points,PRI score of(0.43±0.07)points and PPI score of(1.15±0.08)points.VAS score,PRI score and PPI score of the experimental group were lower than those of the conventional group(P<0.05).After treatment,the conventional group had IL-6 of(65.45±4.85)ng/L,TNF-α of(42.25±1.60)ng/L,and hs-CRP of(24.18±3.39)mg/L;the experimental group had IL-6 of(36.77±3.06)ng/L,TNF-α of(31.07±0.40)ng/L,and hs-CRP of(12.00±1.60)mg/L.After treatment,the inflammatory indicators of the experimental group was lower than that of the control group(P<0.05).After treatment,the conventional group had ALT of(60.26±8.02)U/L,AST of(65.25±7.36)U/L and TBIL of(32.43±6.07)μmol/L;the experimental group had ALT of(31.97±4.85)U/L,AST of(46.78±5.96)U/L and TBIL of(22.01±4.38)μmol/L.After treatment,the liver and bile function indicators of the experimental group was lower than that of the control group(P<0.05).The total effective rate of the experimental group was 97.78%,which was higher than 86.67%of the control group(P<0.05).Conclusion For patients with chronic cholecystitis,Danshi tablet combined with cefazolin sodium has good effect,and can improve clinical symptoms.It is recommended to be widely used.
NETL
NSTL
万方数据
维普
