Study on effect of bevacizumab combined with paclitaxel liposome in the treatment of advanced gastric cancer
Objective To explore the effect of bevacizumab combined with paclitaxel liposome in the treatment of advanced gastric cancer.Methods A total of 98 patients with advanced gastric cancer were selected as the study subjects and divided into a control group and a study group according to random number table method,with 49 cases in each group.The control group was treated with combined chemotherapy of paclitaxel liposome and decitabine,and the study group was treated with bevacizumab based on the control group.Both groups were compared in terms of clinical efficacy,serum growth factors[insulin like growth factor-1(IGF-1)and transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)]levels,quality of life questionnaire(QLQ-52)score,and the occurrence of adverse reactions.Results The total effective rate of the study group was 65.31%,which was higher than 44.90%of the control group(P<0.05).Before treatment,there were no differences in IGF-1,TGF-β1 and VEGF levels between the two groups(P>0.05).After treatment,the study group had IGF-1 of(82.65±5.23)ng/ml,TGF-β1 of(22.45±4.02)ng/ml and VEGF of(92.45±10.25)ng/L,which were significantly lower than(90.56±5.03)ng/ml,(28.95±4.47)ng/ml and(104.52±11.57)ng/L in the control group(P<0.05).Before treatment,there was no difference in QLQ-52 score between the two groups(P>0.05).After treatment,the QLQ-52 score of the study group was(70.52±10.23)points,which was higher than(62.84±8.45)points of the control group(P<0.05).There was no difference in the incidence of gastrointestinal reaction,myelosuppression,liver function damage and peripheral nerve toxicity between the two groups(P>0.05).Conclusion The combination of bevacizumab and paclitaxel liposome in the treatment of advanced gastric cancer is effective,which can effectively inhibit serum growth factor,improve the quality of life of patients,and has clinical popularization value.
BevacizumabPaclitaxel liposomeAdvanced gastric cancer
NETL
NSTL
万方数据
维普
