Efficacy of Saccharomyces boulardii in combination with ganciclovir in the treatment of ulcerative colitis associated with cytomegalovirus infection
Objective To analyze the clinical efficacy of Saccharomyces boulardii in combination with ganciclovir in the treatment of ulcerative colitis(UC)associated with cytomegalovirus(CMV)infection.Methods 60 cases of UC associated with CMV infection were studied and divided into a control group and an observation group by random number grouping,with 30 cases in each group.Patients in the control group were treated with ganciclovir,and patients in the observation group were treated with Saccharomyces bralardii combined with ganciclovir.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]before and after treatment,the time of improvement of clinical symptoms and the conversion rate of cytomegalovirus infection were compared between the two groups.Results After treatment,the observation group had TNF-α of(15.23±2.19)pg/ml and IL-6 of(145.93±11.02)pg/ml,which were lower than(25.32±2.63)and(198.72±11.51)pg/ml in the control group,and the difference was statistically significant(P<0.05).The disappearance time of diarrhea and blood stool were(6.17±1.58)and(4.32±1.35)d in the observation group,which were shorter than(9.87±1.69)and(7.21±1.86)d in the control group;the observation group had higher negative-conversion rate of cytomegalovirus infection of 93.3%than 63.3%in the control group;the difference was statistically significant(P<0.05).The total effective rate of 96.7%in the observation group was higher than 80.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of ulcerative colitis associated with cytomegalovirus infection,the use of Saccharomyces boulardii combined with ganciclovir can improve the level of inflammatory factors,clinical symptom improvement time and clinical treatment effect,which is worthy of promotion and application.
NETL
NSTL
万方数据
维普
