Study on effect of ulinastatin on postoperative immune function in patients undergoing laparoscopic radical resection for colorectal cancer
Objective To explore the effect of ulinastatin on postoperative immune function in patients undergoing laparoscopic radical resection for colorectal cancer.Methods 80 patients with colorectal cancer who underwent laparoscopic radical resection for colorectal cancer were selected as the study subjects,and they were divided into a reference group and a study group according to the coin-tossing method,with 40 cases in each group.The reference group did not receive any drug treatment before surgery,and the study group received ulinastatin treatment before surgery.The CD3+,CD3+CD8+,CD3+CD4+,CD4/CD8 and total incidence of postoperative complications were compared between the two groups.Results The study group had CD3+ of(72.25±2.52)%,CD3+CD8+ of(19.58±2.52)%,CD3+CD4+ of(50.25±2.52)%,and CD4/CD8 of(2.58±0.25),which were significantly higher than(45.39±2.52)%,(13.29±1.27)%,(20.25±3.12)%,and(0.52±0.13)in the reference group(P<0.05).Among the 40 patients in the study group,1 case had infection and 1 case had hemorrhage,and the total number of complications was 2 cases(5.00%).Among the 40 patients in the reference group,2 cases had infection and 2 cases had hemorrhage,and the total number of complications was 4 cases(10.00%).The total incidence of postoperative complications in the study group was not significantly different from that in the reference group(P>0.05).Conclusion The preoperative application of ulinastatin in patients undergoing laparoscopic radical surgery for colorectal cancer can significantly increase their levels of CD3+,CD3+CD8+,CD3+CD4+,and CD4/CD8,without causing an increase in postoperative infection and bleeding,which can promote patients'prognostic recovery.
UlinastatinLaparoscopic radical resection for colorectal cancerColorectal cancerImmune function
NETL
NSTL
万方数据
维普
