Efficacy of cyclosporine A combined with Kanglilong in the treatment of chronic aplastic anemia
Objective To explore the efficacy of cyclosporine A combined with stanozolol tablets(trade name:Kanglilong)in the treatment of chronic aplastic anemia.Methods 90 patients with chronic aplastic anemia were selected.According to the single-even random grouping method,the patients were divided into the observation group and the control group,with 45 patients in each group.The control group was treated with Kanglilong,and the observation group was treated with cyclosporine A based on the control group.The blood routine indexes,quality of life score,main symptom score and reticulocyte absolute value of the two groups were compared.Results The hemoglobin,neutrophil and platelet count in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The emotional role score was(93.74±1.96)points in the observation group and(81.37±1.17)points in the control group;the health status score was(92.65±2.16)points in the observation group and(82.84±1.47)points in the control group;the somatic role score was(93.98±1.79)points in the observation group and(84.13±1.58)points in the control group;the social functioning score was(94.63±2.15)points in the observation group and(85.16±2.76)points in the control group.The scores of emotional role,health status,somatic role and social functioning of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The dizziness and palpitation score was(55.74±2.25)points in the observation group and 60.74±3.65)points in the control group;the anemia score was(61.36±1.59)points in the observation group and(68.69±2.16)points in the control group;the skin bleeding score was(72.36±2.69)points in the observation group and(86.74±3.85)points in the control group;the upper respiratory tract infection score was(69.36±4.36)points in the observation group and(81.26±5.67)points in the control group.The scores of dizziness and palpitation,anemia,skin bleeding,and upper respiratory tract infection in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The reticulocyte absolute value after treatment was(26.44±2.65)×109/L in the observation group and(16.23±2.68)×109/L in the control group.The reticulocyte absolute value in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Cyclosporine A combined with Kanglilong has a good clinical effect in the treatment of chronic aplastic anemia,which can effectively improve the clinical symptoms and blood routine indexes,improve the quality of life of patients,and has high clinical application value.
NETL
NSTL
万方数据
维普
