Observation on the effect of iron protein succinylate in treating severe anemia
Objective To analyze the clinical efficacy of iron protein succinylate in treating patienst with severe anemia.Methods 700 patients with severe anemia were selected as the observation subjects and divided into a control group and an observation group according to the different drugs used in treatment,with 350 cases in each group.The control group was treated with polysaccharide iron complex,and the observation group was treated with iron protein succinylate.Comparison was made on haematological indexes[red blood cell count(RBC),hemoglobin(Hb),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)]and iron metabolism indexes[serum iron(SI),serum ferritin(SF)and total iron binding capacity(TIBC)]before and after treatment,clinical efficacy,and occurrence of adverse reactions after treatment between the two groups.Results In the control group,RBC,Hb,MCV,MCH,SI,SF and TIBC before treatment were(2.18±0.25)×1012/L,(82.65±7.82)g/L,(67.45±4.47)fl,(21.23±2.35)pg,(6.35±1.12)μmol/L,(5.68±1.29)μg/L and(80.45±8.72)μmol/L;after treatment,they were(3.69±0.32)×1012/L,(123.45±8.91)g/L,(73.61±4.82)fl,(24.57±2.80)pg,(16.37±1.72)μmol/L,(62.08±6.52)μg/L and(68.54±7.25)μmol/L.In the observation group,RBC,Hb,MCV,MCH,SI,SF and TIBC before treatment were(2.15±0.31)×1012/L,(82.57±7.93)g/L,(67.38±4.52)fl,(21.20±2.37)pg,(6.30±1.15)μmol/L,(5.62±1.34)μg/L and(80.56±8.81)μmol/L;after treatment,they were(5.34±0.48)×1012/L,(129.58±9.74)g/L,(84.92±5.13)fl,(27.62±3.01)pg,(22.04±2.25)μmol/L,(80.76±7.98)μg/L and(61.89±6.43)μmol/L.Before treatment,there was no significant difference in RBC,Hb,MCV,MCH,SI,SF and TIBC levels between the two groups(P>0.05).After treatment,RBC,Hb,MCV,MCH,SI and SF in both groups were higher than those before treatment,and the observation group was higher than the control group;TIBC in both groups was lower than that before treatment,and the observation group was lower than the control group;the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 98.57%,and there was no statistically significant difference compared to the control group's 98.86%(P>0.05).The incidence of adverse reactions in the control group was 1.71%,and there was no statistically significant difference compared to the observation group's 2.00%(P>0.05).Conclusion For patients with severe anemia,iron protein succinylate has a definite clinical effect,and can effectively improve the iron metabolism function and hematological index concentration of patients,and has a high drug safety.
Polysaccharide iron complexIron protein succinylateSevere anemiaIron deficiency anemiaClinical efficacy
NETL
NSTL
万方数据
维普
