Clinical analysis of Huatan Xifeng Tongluo Decoction combined with edaravone and dexborneol in the treatment of acute cerebral infarction
Objective To explore the efficacy of Huatan Xifeng Tongluo Decoction combined with edaravone and dexborneol in the treatment of acute cerebral infarction(ACI).Methods 205 patients with acute cerebral infarction were divided into an experimental group(103 cases,2 drop-out cases due to loss of follow-up,and finally 101 cases remained)and a control group(102 cases,3 drop-out cases due to loss of follow-up,and finally 99 cases remained)according to random number table method.The control group was treated with edaravone and dexborneol for injection,and the experimental group was treated with Huatan Xifeng Tongluo Decoction on the basis of the control group.Both groups were compared in terms of neurological function[National Institutes of Health Stroke Scale(NIHSS)score and Modified Rankin Scale(mRS)score],self-care ability[Barthel index(BI)],clinical efficacy,hemorheology index(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity),liver and kidney function[glutamic pyruvate transaminase(GPT),glutamic oxaloacetic transaminase(GOT),serum creatinine(Scr),cystatin C(Cys C),β2 microglobulin(β2-MG),retinol binding protein(RBP)],neuron specific enolase,and drug safety.Results After treatment,NIHSS score and mRS score decreased,and BI score increased in both groups;the experimental group had NIHSS score of(4.02±0.68)points and mRS score of(0.98±0.17)points,which were lower than(4.81±0.87)and(1.19±0.21)points in the control group;the experimental group had higher BI score of(72.69±5.32)points than(68.12±5.17)points in the control group;the difference was statistically significant(P<0.05).After treatment,the total effective rate of the experimental group was 91.09%(92/101),which was higher than 80.81%(80/99)of the control group,and the difference was statistically significant(P<0.05).After treatment,the plasma viscosity,whole blood high shear viscosity and whole blood low shear viscosity decreased in both groups;in the experimental group,the plasma viscosity was(1.49±0.27)mPa·s,the whole blood high shear viscosity was(4.01±0.75)mPa·s and the whole blood low shear viscosity was(7.15±1.12)mPa·s,which were lower than(1.72±0.31),(4.43±0.85)and(8.06±1.23)mPa·s in the control group;the difference was statistically significant(P<0.05).There were no significant differences in GPT,GOT,Scr,Cys C,β2-MG and RBP between the two groups before and after treatment(P>0.05).After treatment,NSE in both groups decreased,and the experimental group had lower NSE of(8.14±2.16)ng/ml than(12.23±3.23)ng/ml in the control group.The difference was statistically significant(P<0.05).The incidence of adverse drug reactions in the experimental group and the control group were 5.94%(6/101)and 5.05%(5/99),and the difference was not statistically significant in comparison(P>0.05).Conclusion Huatan Xifeng Tongluo Decoction combined with edaravone and dexborneol in the treatment of acute cerebral infarction can promote the recovery of neurological deficit,enhance self-care ability,improve hemorheology with good safety.
Acute cerebral infarctionHuatan Xifeng Tongluo DecoctionEdaravone and dexborneolCurative effect
万方数据
维普
