Clinical effect analysis of butylphthalide soft capsules combined with edaravone in the treatment of acute cerebral infarction
Objective To analyze the clinical effect of butylphthalide soft capsules combined with edaravone in the treatment of acute cerebral infarction.Methods 50 patients with acute cerebral infarction were divided into an observation group and a control group by random number table,with 25 cases in each group.The control group was treated with conventional treatment plus butylphthalide soft capsules,and the observation group was treated with edaravone on the basis of the control group.Both groups were compared in terms of National Institutes of Health Stroke Scale(NIHSS)score,modified Barthel index,hemorheology indexes[plasma viscosity(PSV),hematocrit(HCT),low shear viscosity(LSV),high shear viscosity(HSV)]before and after treatment,clinical efficacy and incidence of adverse reactions.Results The total effective rate of the observation group was 92.0%,which was higher than 68.0%of the control group,and there was a statistical significance in comparison(P<0.05).After treatment,the observation group had significantly lower NIHSS score of(13.71±2.84)points than(16.52±3.46)points in the control group,and higher Barthel index of(88.23±4.85)points than(78.61±5.34)points in the control group.There was a statistical significance in comparison(P<0.05).After treatment,PSV,HCT,LSV and HSV in the observation group were(1.25±0.11)mPa·s,(39.26±3.22)%,(10.12±1.11)mPa·s and(5.13±2.41)mPa·s,which were lower than(2.62±0.24)mPa·s,(45.62±3.66)%,(12.51±0.24)mPa·s and(6.95±0.27)mPa·s in the control group.There was a statistical significance in comparison(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of butylphthalide soft capsules combined with edaravone in the treatment of acute cerebral infarction can improve neurological function,quality of life,hemorheology,and clinical efficacy,and does not increase the adverse reactions of drug therapy,which is worthy of clinical promotion and application.
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