Study on the effect of high-dose radiotherapy combined with EP chemotherapy on LS-SCLC and its impact on immune function
Objective To explore the effect of high-dose radiotherapy combined with etoposide(EP)chemotherapy on limited-stage small cell lung cancer(LS-SCLC)and its impact on immune function.Methods 100 cases of LS-SCLC patients were divided into a control group and an observation group using a random number table method,with 50 patients in each group.The control group was treated with hyperfractionated radiotherapy and EP chemotherapy,while the observation group was treated with high-dose radiotherapy and EP chemotherapy.The effects,immune function indicators[CD3+,CD4+,CD8+,CD4+/CD8+,natural killer cell(NK)]before and after treatment,and the progression-free survival time,total survival time,2-year survival rate and incidence of adverse events of the two groups were compared.Results The total effective rate of the observation group was 80.00%,which was higher than 58.00%of the control group(P<0.05).After treatment,CD3+,CD4+,CD4+/CD8+and NK cells increased in both groups,and CD8+decreased in both groups;the observation group had CD3+of(66.21±4.06)%,CD4+of(43.10±3.09)%,CD4+/CD8+of(1.72±0.19),and NK cells of(15.12±2.74)%,which were higher than(62.18±3.62)%,(39.16±2.99)%,(1.32±0.24),and(12.07±2.17)%in the control group;the observation group had lower CD8+of(21.09±2.75)%than(24.72±2.65)%in the control group(P<0.05).The progression-free survival time and overall survival time of the observation group were(12.98±2.19)and(20.19±3.27)months,which were longer than(8.27±1.98)and(14.29±2.91)months of the control group;the observation group had higher 2-year survival rate of 68.00%than 42.00%in the control group(P<0.05).The incidence of adverse events in the observation group was 22.00%,which was slightly lower than 32.00%in the control group,but the difference was not significant(P>0.05).Conclusion High-dose radiotherapy and EP chemotherapy have significant effects on the treatment of LS-SCLC,which can effectively regulate the body's immune function,prolong the patient's survival period,and improve survival rate,and they have high safety and can be widely used in clinical practice.
Limited-stage small cell lung cancerHigh-dose radiotherapyCisplatinEtoposideEffectImmune functionSurvival periodAdverse event
万方数据
维普
