Clinical observation of modified Sijunzi Decoction and Shashen Maidong Decoction combined with target therapy in the treatment of EGFR-mutated advanced lung cancer
Objective To explore the effect of modified Sijunzi Decoction and Shashen Maidong Decoction combined with target therapy in the treatment of epidermal growth factor receptor(EGFR)-mutated advanced lung cancer.Methods 60 patients with EGFR-mutated advanced lung cancer were divided into an observation group and a control group according to random number table,with 30 cases in each group.The control group was treated with gefitinib target therapy,and the observation group was treated with modified Sijunzi Decoction and Shashen Maidong Decoction on the basis of the control group.The clinical efficacy,improvement of Karnofsky performance status(KPS)score,occurrence of adverse reactions and immunological indicators(CD3+,CD4+,CD8+,CD4+/CD8+)before and after treatment were compared between the two groups.Results After treatment,the objective effective rate of the observation group was 66.7%,which was higher than 40.0%of the control group,and the difference was statistically significant(P<0.05).After treatment,the total improvement rate of KPS score in the observation group and the control group were 60.0%and 33.3%;the observation group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+increased significantly in both groups and CD8+level decreased compared with those before treatment;the levels of CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group,and the level of CD8+was significantly lower than that in the control group.The difference was statistically significant(P<0.05).The incidence rates of gastrointestinal reaction,rash and liver/kidney injury were 36.7%,30.0%and 23.3%in the observation group,and 63.3%,56.7%and 50.0%in the control group;the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with EGFR-mutated advanced lung cancer,modified Sijunzi Decoction and Shashen Maodong decoction combined with target therapy can improve clinical efficacy,improve clinical symptoms,enhance immune function,reduce the incidence of adverse reactions in patients,and significantly improve their quality of life.
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