Effect of Yupingfeng granules on ventilation function and inflammatory response in patients with allergic rhinitis
Objective To explore the effect of Yupingfeng granules on ventilation function and inflammatory response in patients with allergic rhinitis(AR).Methods 80 patients with AR were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with Yupingfeng granules on the basis of the control group.Both groups were compared in terms of ventilation function[peak expiratory flow rate(PEF),diurnal variation rate of PEF],inflammatory response indexes[interleukin(IL-6),IL-17,IL-23,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),immune function[immunoglobulin(Ig)A,IgG,IgE],symptom score,therapeutic effect,and improvement time of clinical symptoms.Results After treatment,PEF in both groups was higher than that before treatment,and the diurnal variation rate of PEF was lower than that before treatment;the observation group had higher PEF of(73.30±7.91)L/min than(62.97±6.43)L/min in the control group,and lower diurnal variation rate of PEF of(13.34±2.45)%than(17.74±3.65)%in the control group(P<0.05).After treatment,the observation group had IL-6 of(131.52±11.17)ng/L,IL-17 of(3.13±0.27)ng/L,IL-23 of(151.56±18.25)ng/L,CRP of(4.28±0.22)mg/L,and TNF-α of(7.44±1.18)ng/L,which were lower than(159.65±18.15)ng/L,(4.44±0.51)ng/L,(215.31±31.30)ng/L,(6.28±0.94)mg/L,and(12.50±2.20)ng/L in the control group(P<0.05).After treatment,the observation group had IgA of(1.48±0.18)g/L and IgG of(12.65±1.70)g/L,which were higher than(1.03±0.22)and(9.83±1.14)g/L in the control group;the observation group had lower IgE of(418.41±48.36)IU/ml than(625.28±76.29)IU/ml in the control group(P<0.05).After treatment,the scores of nasal discharge,nasal congestion,nasal itching and sneezing in the observation group were lower than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The improvement time of nasal congestion,nasal itching,sneezing and nasal discharge in the observation group were shorter than those in the control group(P<0.05).Conclusion The application of Yupingfeng granules has a significant therapeutic effect for AR patients,and is beneficial for promoting patient recovery.
Allergic rhinitisYupingfeng granulesVentilation function
万方数据
维普
